Multi-omics reveal the gut microbiota-mediated severe foraging environment adaption of small wild ruminants in the Three-River-Source National Park, China
文献类型：期刊论文
| 作者 | Liu, Hongjin; Zhao, Xinquan ; Xu, Shixiao; Zhao, Liang; Han, Xueping; Xu, Xianli; Zhao, Na; Hu, Linyong; Luo, Chongliang; Wang, Xungang
|
| 刊名 | INTEGRATIVE ZOOLOGY
 |
| 出版日期 | 2024 |
| 英文摘要 | The Tibetan antelope (Pantholops hodgsonii), blue sheep (Pseudois nayaur), and Tibetan sheep (Ovis aries) are the dominant small ruminants in the Three-River-Source National Park (TRSNP). However, knowledge about the association between gut microbiota and host adaptability remains poorly understood. Herein, multi-omics sequencing approaches were employed to investigate the gut microbiota-mediated forage adaption in these ruminants. The results revealed that although wild ruminants (WR) of P. hodgsoni and P. nayaur were faced with severe foraging environments with significantly low vegetation coverage and nutrition, the apparent forage digestibility of dry matter, crude protein, and acid detergent fiber was significantly higher than that of O. aries. The 16s rRNA sequencing showed that the gut microbiota in WR underwent convergent evolution, and alpha diversity in these two groups was significantly higher than that in O. aries. Moreover, indicator species, including Bacteroidetes and Firmicutes, exhibited positive relationships with apparent forage digestibility, and their relative abundances were enriched in the gut of WR. Enterotype analysis further revealed that enterotype 1 belonged to WR, and the abundance of fatty acid synthesis metabolic pathway-related enzyme genes was significantly higher than enterotype 2, represented by O. aries. Besides, the metagenomic analysis identified 14 pathogenic bacterial species, among which 10 potentially pathogenic bacteria were significantly enriched in the gut microbiota of O. aries. Furthermore, the cellulolytic strains and genes encoding cellulase and hemicellulase were significantly enriched in WR. In conclusion, our results provide new evidence of gut microbiota to facilitate wildlife adaption in severe foraging environments of the TRSNP, China.This research reveals the gut microbiota-mediated severe foraging environment adaptation of wild small ruminants in the Three-River-Source National Park. Unlike Tibetan sheep (TS), blue sheep (PN and Tibetan antelope (TA) often grazed low-quality herbage in a wildness environment, and the higher microbial diversity and resilient network characteristics enabled the hosts to cope with flexible feeding environments. Environmental heterogeneity made the gut microbiota of PN and TA exhibit convergent evolutionary characteristics to adapt to nutritional stress from the habitats. Moreover, a study on microbial enterotypes revealed the two enterotypes, especially E1 exhibited by PN and TA, exhibit higher forage utilization potential and typical microorganisms involved in fatty acid and oxidative phosphorylation pathways play vital roles in energy production and maintaining the hosts' energy balance in the face of cold, anoxia, and food scarcity situation. Furthermore, the less abundant the microbial pathogens, the more abundant the forage-degrading microbiota, and the CAZymes genes encoding cellulose and hemicellulase enable wild small ruminants to better adapt to low quantity and poor-quality forage environments. image |
| 源URL | [http://210.75.249.4/handle/363003/62041]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Hongjin,Zhao, Xinquan,Xu, Shixiao,et al. Multi-omics reveal the gut microbiota-mediated severe foraging environment adaption of small wild ruminants in the Three-River-Source National Park, China[J]. INTEGRATIVE ZOOLOGY,2024. |
| APA | Liu, Hongjin.,Zhao, Xinquan.,Xu, Shixiao.,Zhao, Liang.,Han, Xueping.,...&Guo, Tongqing.(2024).Multi-omics reveal the gut microbiota-mediated severe foraging environment adaption of small wild ruminants in the Three-River-Source National Park, China.INTEGRATIVE ZOOLOGY. |
| MLA | Liu, Hongjin,et al."Multi-omics reveal the gut microbiota-mediated severe foraging environment adaption of small wild ruminants in the Three-River-Source National Park, China".INTEGRATIVE ZOOLOGY (2024). |
入库方式： OAI收割
来源：西北高原生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。