The Antioxidant Salidroside Ameliorates the Quality of Postovulatory Aged Oocyte and Embryo Development in Mice
文献类型：期刊论文
| 作者 | Liu, Kexiong; Zhang, Luyao; Xu, Xiaoling; Xiao, Linli; Wen, Junhui; Zhang, Hanbing; Zhao, Shuxin; Qiao, Dongliang; Bai, Jiahua; Liu, Yan |
| 刊名 | ANTIOXIDANTS
 |
| 出版日期 | 2024 |
| 卷号 | 13期号:2 |
| 英文摘要 | Postovulatory aging is known to impair the oocyte quality and embryo development due to oxidative stress in many different animal models, which reduces the success rate or pregnancy rate in human assisted reproductive technology (ART) and livestock timed artificial insemination (TAI), respectively. Salidroside (SAL), a phenylpropanoid glycoside, has been shown to exert antioxidant and antitumor effects. This study aimed to investigate whether SAL supplementation could delay the postovulatory oocyte aging process by alleviating oxidative stress. Here, we show that SAL supplementation decreases the malformation rate and recovers mitochondrial dysfunction including mitochondrial distribution, mitochondrial membrane potential (Delta psi) and ATP content in aged oocytes. In addition, SAL treatment alleviates postovulatory aging-caused oxidative stress such as higher reactive oxygen species (ROS) level, lower glutathione (GSH) content and a reduced expression of antioxidant-related genes. Moreover, the cytoplasmic calcium ([Ca2+]c) and mitochondrial calcium ([Ca2+]mt) of SAL-treated oocytes return to normal levels. Notably, SAL suppresses the aging-induced DNA damage, early apoptosis and improves spindle assembly in aged oocytes, ultimately elevating the embryo developmental rates and embryo quality. Finally, the RNA-seq and confirmatory experience showed that SAL promotes protective autophagy in aged oocytes by activating the MAPK pathway. Taken together, our research suggests that supplementing SAL is an effective and feasible method for preventing postovulatory aging and preserving the oocyte quality, which potentially contributes to improving the successful rate of ART or TAI. |
| 源URL | [http://210.75.249.4/handle/363003/62097]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Kexiong,Zhang, Luyao,Xu, Xiaoling,et al. The Antioxidant Salidroside Ameliorates the Quality of Postovulatory Aged Oocyte and Embryo Development in Mice[J]. ANTIOXIDANTS,2024,13(2). |
| APA | Liu, Kexiong.,Zhang, Luyao.,Xu, Xiaoling.,Xiao, Linli.,Wen, Junhui.,...&Liu, Yan.(2024).The Antioxidant Salidroside Ameliorates the Quality of Postovulatory Aged Oocyte and Embryo Development in Mice.ANTIOXIDANTS,13(2). |
| MLA | Liu, Kexiong,et al."The Antioxidant Salidroside Ameliorates the Quality of Postovulatory Aged Oocyte and Embryo Development in Mice".ANTIOXIDANTS 13.2(2024). |
入库方式： OAI收割
来源：西北高原生物研究所
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