Plant Secondary Compounds Promote White Adipose Tissue Browning via Modulation of the Gut Microbiota in Small Mammals
文献类型：期刊论文
| 作者 | Ren, Shien; Zhang, Liangzhi; Tang, Xianjiang; Fan, Chao; Zhao, Yaqi; Cheng, Qi; Zhang, Yanming
|
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2023 |
| 卷号 | 24期号:24 |
| 英文摘要 | The browning of white adipose tissue (WAT) is a promising area of research for treating metabolic disorders and obesity in the future. However, studies on plant secondary compounds promoting WAT browning are limited. Herein, we explored the effects of swainsonine (SW) on gut microbiota and WAT browning in captive pikas. SW inhibited body mass gain, increased brown adipose tissue (BAT) mass, and induced WAT browning in pikas. The 16S rDNA sequencing revealed a significant reduction in the alpha diversity and altered community structure of the gut microbiota in captive pikas. However, the addition of SW to the diet significantly increased the alpha diversity of gut microbiota and the relative abundance of Akkermansia, Prevotella, and unclassified_f__Lachnospiraceae, along with the complexity of the microbial co-occurrence network structure, which decreased in the guts of captive pikas. Functional profiles showed that SW significantly decreased the relative abundances of energy metabolism, lipid metabolism, and glycan biosynthesis and metabolism, which were enriched in captive pikas. Furthermore, SW decreased deterministic processes of gut microbiota assembly in July and increased them in November. Finally, the genera Prevotella and unclassified_f__Prevotellaceae were positively correlated with BAT mass. Our results highlighted that plant secondary compounds promote WAT browning by modulating the gut microbiota in small mammals. |
| 源URL | [http://210.75.249.4/handle/363003/62136]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Ren, Shien,Zhang, Liangzhi,Tang, Xianjiang,et al. Plant Secondary Compounds Promote White Adipose Tissue Browning via Modulation of the Gut Microbiota in Small Mammals[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(24). |
| APA | Ren, Shien.,Zhang, Liangzhi.,Tang, Xianjiang.,Fan, Chao.,Zhao, Yaqi.,...&Zhang, Yanming.(2023).Plant Secondary Compounds Promote White Adipose Tissue Browning via Modulation of the Gut Microbiota in Small Mammals.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(24). |
| MLA | Ren, Shien,et al."Plant Secondary Compounds Promote White Adipose Tissue Browning via Modulation of the Gut Microbiota in Small Mammals".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.24(2023). |
入库方式： OAI收割
来源：西北高原生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。