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Association between City-Level Particulate Matter Exposure and Frailty among Middle-Aged and Older Adults in China

文献类型：期刊论文

作者Wu, Di4; Guo, Zhen4; Xue, Hui4; Fan, Lijun4; Liao, Yilan3; Nyame, Linda4; Cui, Mengjing4; Tian, Yong1,2; Ruan, Zengliang4; Du, Wei4
刊名GERONTOLOGY
出版日期2024-09-06
卷号N/A页码:14
关键词Particulate matter exposure Frailty Middle-aged and older adults Exposure-response relationship China
ISSN号0304-324X
DOI10.1159/000539517
产权排序2
英文摘要Introduction: The effects of exposure to particulate matter and frailty, as well as its exposure-response relationship, have not been effectively explored. This study aimed to explore the association between long-term exposure to particulate matter and frailty state and each dimension in Chinese middle-aged and older adults, in addition to the exposure-response relationship. Methods: The data were obtained from the National Urban Air Quality Real-Time Dissemination Platform and China Health and Retirement Longitudinal Study (CHARLS). Frailty was measured by a frailty index containing 39 indicators. Annual averages of seven pollutants were calculated from hourly monitoring data. We used multilevel regression modeling to explore the association between long-term exposure to particulate matter and frailty. Meanwhile, we explored the exposure-response relationship based on a multilevel generalized summation model. We performed a sensitivity analysis using a multi-pollution model and a quantile-based g-computation (QGC) model. Results: A total of 15,611 participants were included in the analysis. We find that long-term exposure to PM2.5 was associated with an increased risk of pre-frailty and frailty (all p < 0.05). PMc and PM10 exhibited similar associations. The exposure-response relationship between PM2.5 showed a linear relationship, whereas the exposure-response relationship between PM10, PMc showed a nonlinear relationship. Elevated PM2.5 concentrations showed significant positive associations with the number of chronic disease score, IADL score, and functional limitation status score (all p < 0.05). PM10 and PMc showed similar positive correlations. These results remained robust after sensitivity analyses using a multi-pollution model and QGC model. Conclusion: Chronic exposure to particulate matter was significantly associated with increased risk of frailty. The exposure-response relationship between PM2.5 concentration and frailty showed a linear relationship, and the exposure-response relationship between PM10 and PMc showed a nonlinear relationship. Exposure to a mixture of pollutants carried a higher risk of frailty than exposure to a single pollutant.
WOS关键词AMBIENT AIR-POLLUTION ; LONG-TERM EXPOSURE ; PREVALENCE ; COHORT ; HEALTH ; PM2.5
资助项目National Social Science Foundation of China[23CGL072] ; Ministry of Science and Technology[G2023141005L] ; Jiangsu Provincial Department of Science and Technology
WOS研究方向Geriatrics & Gerontology
语种英语
WOS记录号WOS:001311200500001
出版者KARGER
资助机构National Social Science Foundation of China ; Ministry of Science and Technology ; Jiangsu Provincial Department of Science and Technology
源URL[http://ir.igsnrr.ac.cn/handle/311030/208636]  
专题资源与环境信息系统国家重点实验室_外文论文
通讯作者Ruan, Zengliang; Du, Wei
作者单位1.Nanjing Univ Informat Sci & Technol, Common Prosper Res Inst, Nanjing, Peoples R China
2.Nanjing Univ Informat Sci & Technol, Sch Law & Polit, Nanjing, Peoples R China
3.Chinese Acad Sci, State Key Lab Resources & Environm Informat Syst, Inst Geog Sci & Nat Resources Res, Beijing, Peoples R China
4.Southeast Univ, Sch Publ Hlth, Nanjing, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Di,Guo, Zhen,Xue, Hui,et al. Association between City-Level Particulate Matter Exposure and Frailty among Middle-Aged and Older Adults in China[J]. GERONTOLOGY,2024,N/A:14.
APA Wu, Di.,Guo, Zhen.,Xue, Hui.,Fan, Lijun.,Liao, Yilan.,...&Du, Wei.(2024).Association between City-Level Particulate Matter Exposure and Frailty among Middle-Aged and Older Adults in China.GERONTOLOGY,N/A,14.
MLA Wu, Di,et al."Association between City-Level Particulate Matter Exposure and Frailty among Middle-Aged and Older Adults in China".GERONTOLOGY N/A(2024):14.

入库方式： OAI收割

来源：地理科学与资源研究所

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