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Synchrotron Radiation: A Key Tool for Drug Discovery

文献类型：期刊论文

作者Li, Fengcheng1,3; Liu, Runze3; Li, Wenjun1,3; Xie, Mingyuan2; Qin, Song1,3
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2024-12-01
卷号114页码:10
关键词Synchrotron radiation Drug discovery Protein crystals Structure determination Ligand screening
ISSN号0960-894X
DOI10.1016/j.bmcl.2024.129990
通讯作者Xie, Mingyuan(xiemy@mail.iasf.ac.cn) ; Qin, Song(sqin@yic.ac.cn)
英文摘要Synchrotron radiation is extensively utilized in the domains of materials science, physical chemistry, and life science, resulting from its high intensity, exceptional monochromaticity, superior collimation, and broad wave spectrum. This top-notch light source has also made significant contributions to the progress of biomedicine. The advancement of synchrotron radiation-based X-ray and protein crystallography technologies has created new prospects for drug discovery. These innovative techniques have opened up exciting avenues in the field. The investigation of protein crystal structures and the elucidation of the spatial configuration of biological macromolecules have revealed intricate details regarding the modes of protein binding. Furthermore, the screening of crystal polymorphs and ligands has laid the groundwork for rational drug modification and the improvement of drug physicochemical properties. As science and technology continue to advance, the techniques for analyzing structures using synchrotron radiation sources and the design of corresponding crystallographic beamline stations are undergoing continuous enhancement. These cutting-edge tools and facilities are expected to expedite the drug development process and rectify the current situation of a lack of targeted drugs.
WOS关键词SERIAL FEMTOSECOND CRYSTALLOGRAPHY ; CRYSTAL-STRUCTURE ; SMALL-ANGLE ; MACROMOLECULAR CRYSTALLOGRAPHY ; DATA-COLLECTION ; LIGAND COMPLEXES ; RAY PROBE ; TRENDS ; NANOPARTICLES ; POLYMORPHS
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:001342323600001
资助机构National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province ; Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast ; Chinese Academy of Sciences
源URL[http://ir.yic.ac.cn/handle/133337/37755]  
专题中国科学院烟台海岸带研究所
通讯作者Xie, Mingyuan; Qin, Song
作者单位1.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266112, Peoples R China
2.Inst Adv Sci Facil, Shenzhen 518107, Guangdong, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Li, Fengcheng,Liu, Runze,Li, Wenjun,et al. Synchrotron Radiation: A Key Tool for Drug Discovery[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2024,114:10.
APA Li, Fengcheng,Liu, Runze,Li, Wenjun,Xie, Mingyuan,&Qin, Song.(2024).Synchrotron Radiation: A Key Tool for Drug Discovery.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,114,10.
MLA Li, Fengcheng,et al."Synchrotron Radiation: A Key Tool for Drug Discovery".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 114(2024):10.

入库方式： OAI收割

来源：烟台海岸带研究所

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