Detrimental effects of glyphosate on muscle metabolism in grass carp ( Ctenopharyngodon idellus)
文献类型：期刊论文
| 作者 | Yan, Biao1,2; Luo, Lijun2,5; Zhang, Yindan2; Men, Jun3; Guo, Yongyong2; Wu, Shengmin4; Han, Jian2; Zhou, Bingsheng2 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2024-11-01 |
| 卷号 | 276页码:8 |
| 关键词 | Glyphosate Grass carp Muscle Metabolomics Oxidative damage |
| ISSN号 | 0166-445X |
| DOI | 10.1016/j.aquatox.2024.107122 |
| 通讯作者 | Wu, Shengmin(wsm@nies.org) ; Han, Jian(hanjian@ihb.ac.cn) |
| 英文摘要 | Glyphosate, a commonly used herbicide, has been associated with environmental pollution and potential health risks to aquatic organisms. This study investigated the effects of glyphosate on the muscle metabolism of grass carp (Ctenopharyngodon idellus) following exposure to environmentally relevant concentrations. Over a 14-day exposure period to varying glyphosate levels, significant disruptions were observed in antioxidant capacity and muscle health. These disruptions were evidenced by reductions in total antioxidant capacity (T-AOC), increases in malondialdehyde (MDA) levels, and decreases in activities of glutathione peroxidase (GSH-PX) and catalase (CAT). Furthermore, exposure to glyphosate resulted in a reduction of vitamin E content and an elevation of hormonal levels, suggesting the potential for endocrine disruption. Metabolomics analysis identified 605 distinct metabolites, with notable alterations in amino acid, carbohydrate, and nucleotide metabolism pathways. Specifically, arginine and glutathione metabolisms were severely impacted, with decreases in key amino acids such as glycine and glutathione at higher glyphosate concentrations. Nucleotide metabolism, particularly purine synthesis, was also significantly affected, with reduced levels of deoxyguanosine and other purine-related compounds. The study further investigated the origins of these differential metabolites using the MetOrigin platform, suggesting a potential involvement of the intestinal microbiota in the metabolic response to glyphosate. These findings highlight the multifaceted adverse effects of glyphosate on fish muscle, including oxidative stress and metabolic dysregulation, which may contribute to diminished muscle quality and health risks for aquatic organisms. |
| WOS关键词 | HERBICIDE ; MECHANISMS ; EXPRESSION ; GROWTH |
| WOS研究方向 | Marine & Freshwater Biology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001341087900001 |
| 资助机构 | Open Project of State Environ-mental Protection Key Laboratory of Pesticide Environmental Assess-ment and Pollution Control, National Key Research and Development Program of China ; Natural Science Foundation of Hubei province |
| 源URL | [http://ir.yic.ac.cn/handle/133337/37770]  |
| 专题 | 中国科学院烟台海岸带研究所 |
| 通讯作者 | Wu, Shengmin; Han, Jian |
| 作者单位 | 1.Hubei Univ Sci & Technol, Sch Basic Med Sci, Xianning 437100, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Anal & Testing Ctr, Inst Hydrobiol, Wuhan 430072, Peoples R China 4.Minist Ecol & Environm, Nanjing Inst Environm Sci, Nanjing 210042, Peoples R China 5.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Biao,Luo, Lijun,Zhang, Yindan,et al. Detrimental effects of glyphosate on muscle metabolism in grass carp ( Ctenopharyngodon idellus)[J]. AQUATIC TOXICOLOGY,2024,276:8. |
| APA | Yan, Biao.,Luo, Lijun.,Zhang, Yindan.,Men, Jun.,Guo, Yongyong.,...&Zhou, Bingsheng.(2024).Detrimental effects of glyphosate on muscle metabolism in grass carp ( Ctenopharyngodon idellus).AQUATIC TOXICOLOGY,276,8. |
| MLA | Yan, Biao,et al."Detrimental effects of glyphosate on muscle metabolism in grass carp ( Ctenopharyngodon idellus)".AQUATIC TOXICOLOGY 276(2024):8. |
入库方式： OAI收割
来源：烟台海岸带研究所
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