中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 中科院海岸带环境过程与生态修复重点实验室
An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy

文献类型：期刊论文

作者Lu, Pengpeng1,2; Huang, Yan1,2; Zhang, Caiyun1; Fu, Lili1,2; Wang, Xiaoyan1,2; Chen, Lingxin1,2,3
刊名TALANTA
出版日期2022-03-01
卷号239页码:9
关键词Cytochrome P450 Fluorescence imaging Chemotherapy Liver cancer
ISSN号0039-9140
DOI10.1016/j.talanta.2021.123111
通讯作者Huang, Yan(yhuang@yic.ac.cn) ; Wang, Xiaoyan(wangxy@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Cancer is a complex disease with very high incidence and mortality rates every year. However, cancer drug resistance greatly mitigates the cure rates of tumors, and cytochrome P450 (CYP450) plays an important role in the development of cisplatin resistance. We developed the aggregation-induced emission luminogen (AIEgen) TPE-CYP to monitor the changes in CYP450. The TPE-CYP fluorescent probe was successfully used to assess CYP450 levels in tumor cells and tumor tissue sections. This study presented that CYP450 level in HepG2/DDP cells (cisplatin-resistant cells) was higher than that in HepG2 cells, and the inhibition of CYP450 by 1-ABT effectively improved the tumor resistance. Thus, CYP450 plays a key role in the development of tumor resistance. The synergistic effect of 1-ABT and the chemotherapeutic agent cisplatin was superior to that of cisplatin alone in tumor-bearing mice. The TPE-CYP probe will provide an idea for the clinical implementation of individualized tumor treatment strategies, through the accurate monitoring of CYP450.
WOS关键词CYTOCHROME-P450 ISOFORMS ; DRUG-RESISTANCE ; PRODRUG AQ4N ; N-OXIDES ; THERAPY ; HYPOXIA ; ACTIVATION ; EXPRESSION ; METABOLISM ; MECHANISMS
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000729414400006
资助机构National Nature Science Foundation of China ; science and technology innovation development plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization
源URL[http://ir.yic.ac.cn/handle/133337/37960]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Huang, Yan; Wang, Xiaoyan; Chen, Lingxin
作者单位1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
3.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Pengpeng,Huang, Yan,Zhang, Caiyun,et al. An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy[J]. TALANTA,2022,239:9.
APA Lu, Pengpeng,Huang, Yan,Zhang, Caiyun,Fu, Lili,Wang, Xiaoyan,&Chen, Lingxin.(2022).An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy.TALANTA,239,9.
MLA Lu, Pengpeng,et al."An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy".TALANTA 239(2022):9.

入库方式： OAI收割

来源：烟台海岸带研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。