Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials
文献类型：期刊论文
| 作者 | Zhang, Jingjing1; Wang, Linqing1,2; Mi, Yingqi1; Dong, Fang1 ; Guo, Zhanyong1,2
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2024-10-01 |
| 卷号 | 22期号:10页码:16 |
| 关键词 | acetylsalicylic acid antibacterial activity anti-inflammatory activity quaternized chitosan hydrogel films |
| DOI | 10.3390/md22100450 |
| 通讯作者 | Mi, Yingqi(yqmi@yic.ac.cn) ; Guo, Zhanyong(zyguo@yic.ac.cn) |
| 英文摘要 | The aim of the current study is to develop chitosan-based biomaterials which can sustainably release acetylsalicylic acid while presenting significant biological activity. Herein, an innovative ionic bonding strategy between hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and acetylsalicylic acid (AA) was proposed, skillfully utilizing the electrostatic attraction of the ionic bond to achieve the controlled release of drugs. Based on this point, six crosslinked N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan acetylsalicylic acid salt (CHACAA) hydrogel films with varying acetylsalicylic acid contents were prepared by a crosslinking reaction. The results of 1H nuclear magnetic resonance spectroscopy (1H NMR) and scanning electron morphology (SEM) confirmed the crosslinked structure, while the obtained hydrogel films possessed favorable thermal stability, mechanical properties, and swelling ability. In addition, the drug release behavior of the hydrogel films was also investigated. As expected, the prepared hydrogel films demonstrated the capability for the sustainable release of acetylsalicylic acid due to ion pair attraction dynamics. Furthermore, the bioactivities of CHACAA-3 and CHACAA-4 hydrogel films with acetylsalicylic acid molar equivalents of 1.25 and 1.5 times those of HACC were particularly pronounced, which not only exhibited an excellent drug sustained-release ability and antibacterial effect, but also had a higher potential for binding and scavenging inflammatory factors, including NO and TNF-alpha. These findings suggest that CHACAA-3 and CHACAA-4 hydrogel films hold great potential for applications in wound dressing, tissue engineering scaffolds, and drug carriers. |
| WOS关键词 | ANTIBACTERIAL ACTIVITY ; ASPIRIN ; PREVENTION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001343143800001 |
| 资助机构 | Natural Science Foundation of Shandong Province of China ; China Postdoctoral Science Foundation ; Chinese Academy of Sciences - Natural Science Foundation of Shandong Province of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/37844]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Mi, Yingqi; Guo, Zhanyong |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jingjing,Wang, Linqing,Mi, Yingqi,et al. Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials[J]. MARINE DRUGS,2024,22(10):16. |
| APA | Zhang, Jingjing,Wang, Linqing,Mi, Yingqi,Dong, Fang,&Guo, Zhanyong.(2024).Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials.MARINE DRUGS,22(10),16. |
| MLA | Zhang, Jingjing,et al."Preparation and Properties of Crosslinked Quaternized Chitosan-Based Hydrogel Films Ionically Bonded with Acetylsalicylic Acid for Biomedical Materials".MARINE DRUGS 22.10(2024):16. |
入库方式： OAI收割
来源：烟台海岸带研究所
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