ExomiRHub: A comprehensive database for hosting and analyzing human disease-related extracellular microRNA transcriptomics data
文献类型：期刊论文
| 作者 | Liu, Yang1,2,3,4; Min, Zhuochao5,6; Mo, Jing4; Ju, Zhen2; Chen, Jianliang3; Liang, Weiling3; Zhang, Lantian1; Li, Hanguang3; Chan, Godfrey Chi-Fung3; Wei, Yanjie2,7 |
| 刊名 | COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 23页码:3104-3116 |
| 关键词 | MiRNA Extracellular vesicle Exosome Cancer Liquid biopsy |
| ISSN号 | 2001-0370 |
| DOI | 10.1016/j.csbj.2024.07.024 |
| 英文摘要 | Extracellular microRNA (miRNA) expression data generated by different laboratories exhibit heterogeneity, which poses challenges for biologists without bioinformatics expertise. To address this, we introduce ExomiRHub (http://www.biomedical-web.com/exomirhub/), a user-friendly database designed for biologists. This database incorporates 191 human extracellular miRNA expression datasets associated with 112 disease phenotypes, 62 treatments, and 24 genotypes, encompassing 29,198 and 23 sample types. ExomiRHub also integrates 16,012 miRNA transcriptomes of 156 cancer subtypes from The Cancer Genome Atlas. All the data in ExomiRHub were further standardized and curated with annotations. The platform offers 25 analytical functions, including differential expression, co-expression, Weighted Gene Co-Expression Network Analysis (WGCNA), feature selection, and functional enrichment, enabling users to select samples, define groups, and customize parameters for analyses. Moreover, ExomiRHub provides a web service that allows biologists to analyze their uploaded miRNA expression data. Four additional tools were developed to evaluate the functions and targets of miRNAs and miRNA variations. Through ExomiRHub, we identified extracellular miRNA biomarkers associated with angiogenesis for monitoring glioma progression, demonstrating its potential to significantly accelerate the discovery of extracellular miRNA biomarkers. |
| 资助项目 | National Natural Science Foundation of China[32100513] ; National Natural Science Foundation of China[62272449] ; Basic and Applied Basic Research Foundation of Guangdong Province, China[2020A1515110528] ; Basic and Applied Basic Research Foundation of Guangdong Province, China[2021B0101310002] ; Basic and Applied Basic Research Foundation of Guangzhou, China[SL2023A04J00291] ; Strategic Priority Project of Chinese Academy of Sciences, China[XDB38050100] ; Youth Innovation Pro-motion Association of Chinese Academy of Sciences, China[Y2021101] ; Shenzhen Basic Research Fund, China[RCYX20200714114734194] ; Shenzhen Science and Technology Program, China[KQTD20200820113106007] ; Science and Technology Program of Guangzhou, China[2024A04J3341] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:001292067900001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/39643]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Chan, Godfrey Chi-Fung; Wei, Yanjie; Zhang, Wenliang |
| 作者单位 | 1.Guangzhou Med Univ, Guangzhou Med Univ GIBH Joint Sch Life Sci, Affiliated Hosp 1,TheGuangdong-Hong Kong MacaoJoin, Key Lab Adv Interdisciplinary Studies, Hong Kong 510182, Peoples R China 2.Chinese Acad Sci, Ctr High Performance Comp, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 3.Univ Hong Kong, Shenzhen Hosp, Dept Pediat, Shenzhen 518053, Peoples R China 4.Outstanding Biotechnol Co Ltd, Dept Bioinformat, Shenzhen 518026, Peoples R China 5.Tel Aviv Univ, George S Wise Fac Life Sci, Sch Zool, IL-6997801 Tel Aviv, Israel 6.Univ Elect Sci & Technol China, Sch Informat & Software Engn, Chengdu 610054, Peoples R China 7.Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Key Lab Hlth Informat, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Min, Zhuochao,Mo, Jing,et al. ExomiRHub: A comprehensive database for hosting and analyzing human disease-related extracellular microRNA transcriptomics data[J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,2024,23:3104-3116. |
| APA | Liu, Yang.,Min, Zhuochao.,Mo, Jing.,Ju, Zhen.,Chen, Jianliang.,...&Zhang, Wenliang.(2024).ExomiRHub: A comprehensive database for hosting and analyzing human disease-related extracellular microRNA transcriptomics data.COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,23,3104-3116. |
| MLA | Liu, Yang,et al."ExomiRHub: A comprehensive database for hosting and analyzing human disease-related extracellular microRNA transcriptomics data".COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 23(2024):3104-3116. |
入库方式： OAI收割
来源：计算技术研究所
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