中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 计算技术研究所
  3. 中国科学院计算技术研究所
  4. 中国科学院计算技术研究所期刊论文
  5. 英文
Impaired GPX4 activity elicits ferroptosis in alveolar type II cells promoting PHMG-induced pulmonary fibrosis development

文献类型：期刊论文

作者Zhang, Wanjun1,2; Sun, Zhaolong1,2; Cheng, Wenting2; Li, Xin2; Zhang, Jianzhong2; Li, Yanting2; Tan, Haining3; Ji, Xiaoya2; Zhang, Lin1,2; Tang, Jinglong1,2
刊名ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
出版日期2024-08-01
卷号281页码:13
关键词Polyhexamethylene guanidine Pulmonary fibrosis Ferroptosis GPX4 activity Lipid peroxidation
ISSN号0147-6513
DOI10.1016/j.ecoenv.2024.116680
英文摘要Inhaling polyhexamethylene guanidine (PHMG) aerosol, a broad-spectrum disinfectant, can lead to severe pulmonary fibrosis. Ferroptosis, a form of programmed cell death triggered by iron-dependent lipid peroxidation, is believed to play a role in the chemical-induced pulmonary injury. This study aimed to investigate the mechanism of ferroptosis in the progression of PHMG-induced pulmonary fibrosis. C57BL/6 J mice and the alveolar type II cell line MLE-12 were used to evaluate the toxicity of PHMG in vivo and in vitro, respectively. The findings indicated that iron deposition was observed in PHMG induced pulmonary fibrosis mouse model and ferroptosis related genes have changed after 8 weeks PHMG exposure. Additionally, there were disturbances in the antioxidant system and mitochondrial damage in MLE-12 cells following a 12-hour treatment with PHMG. Furthermore, the study observed an increase in lipid peroxidation and a decrease in GPX4 activity in MLE-12 cells after exposure to PHMG. Moreover, pretreatment with the ferroptosis inhibitors Ferrostatin-1 (Fer-1) and Liproxstatin-1 (Lip-1) not only restored the antioxidant system and GPX4 activity but also mitigated lipid peroxidation. Current data exhibit the role of ferroptosis pathway in PHMG-induced pulmonary fibrosis and provide a potential target for future treatment.
资助项目National Natural Science Foundation of China[82273669] ; National Natural Science Foundation of China[82204088] ; National Natural Science Foundation of China[82241086] ; Taishan Scholars Program of Shandong Province ; Innovation and Technology Program for the Excellent Youth Scholars of Higher Education of Shandong Province[2022KJ295]
WOS研究方向Environmental Sciences & Ecology ; Toxicology
语种英语
WOS记录号WOS:001265323400001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.204/handle/2XEOYT63/39860]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Zhang, Lin; Tang, Jinglong
作者单位1.Qingdao Univ, Shandong Prov Maternal & Child Hlth Care Hosp, Jinan 250001, Peoples R China
2.Qingdao Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Res Ctr Intelligent Comp Syst, Inst Comp Technol, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Wanjun,Sun, Zhaolong,Cheng, Wenting,et al. Impaired GPX4 activity elicits ferroptosis in alveolar type II cells promoting PHMG-induced pulmonary fibrosis development[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2024,281:13.
APA Zhang, Wanjun.,Sun, Zhaolong.,Cheng, Wenting.,Li, Xin.,Zhang, Jianzhong.,...&Tang, Jinglong.(2024).Impaired GPX4 activity elicits ferroptosis in alveolar type II cells promoting PHMG-induced pulmonary fibrosis development.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,281,13.
MLA Zhang, Wanjun,et al."Impaired GPX4 activity elicits ferroptosis in alveolar type II cells promoting PHMG-induced pulmonary fibrosis development".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 281(2024):13.

入库方式： OAI收割

来源：计算技术研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。