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Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis

文献类型：期刊论文

作者Li, Ziang1,2; Cheng, Sijing1; Guo, Bo3; Ding, Lu4,5; Liang, Yu6; Shen, Yinghan7; Li, Jinyue8; Hu, Yiqing9; Long, Tianxin1; Guo, Xinli1
刊名EUROPEAN HEART JOURNAL
出版日期2024-07-02
页码16
关键词Exercise Aortic stenosis Aortic regurgitation Mitral regurgitation Aortic valve replacement
ISSN号0195-668X
DOI10.1093/eurheartj/ehae406
英文摘要Background and Aims Physical activity has proven effective in preventing atherosclerotic cardiovascular disease, but its role in preventing degenerative valvular heart disease (VHD) remains uncertain. This study aimed to explore the dose-response association between moderate to vigorous physical activity (MVPA) volume and the risk of degenerative VHD among middle-aged adults.Methods A full week of accelerometer-derived MVPA data from 87 248 UK Biobank participants (median age 63.3, female: 56.9%) between 2013 and 2015 were used for primary analysis. Questionnaire-derived MVPA data from 361 681 UK Biobank participants (median age 57.7, female: 52.7%) between 2006 and 2010 were used for secondary analysis. The primary outcome was the diagnosis of incident degenerative VHD, including aortic valve stenosis (AS), aortic valve regurgitation (AR), and mitral valve regurgitation (MR). The secondary outcome was VHD-related intervention or mortality.Results In the accelerometer-derived MVPA cohort, 555 incident AS, 201 incident AR, and 655 incident MR occurred during a median follow-up of 8.11 years. Increased MVPA volume showed a steady decline in AS risk and subsequent AS-related intervention or mortality risk, levelling off beyond approximately 300 min/week. In contrast, its association with AR or MR incidence was less apparent. The adjusted rates of AS incidence (95% confidence interval) across MVPA quartiles (Q1-Q4) were 11.60 (10.20, 13.20), 7.82 (6.63, 9.23), 5.74 (4.67, 7.08), and 5.91 (4.73, 7.39) per 10 000 person-years. The corresponding adjusted rates of AS-related intervention or mortality were 4.37 (3.52, 5.43), 2.81 (2.13, 3.71), 1.93 (1.36, 2.75), and 2.14 (1.50, 3.06) per 10 000 person-years, respectively. Aortic valve stenosis risk reduction was also observed with questionnaire-based MVPA data [adjusted absolute difference Q4 vs. Q1: AS incidence, -1.41 (-.67, -2.14) per 10 000 person-years; AS-related intervention or mortality, -.38 (-.04, -.88) per 10 000 person-years]. The beneficial association remained consistent in high-risk populations for AS, including patients with hypertension, obesity, dyslipidaemia, and chronic kidney disease.Conclusions Higher MVPA volume was associated with a lower risk of developing AS and subsequent AS-related intervention or mortality. Future research needs to validate these findings in diverse populations with longer durations and repeated periods of activity monitoring. Structured Graphical Abstract Moderate to vigorous physical activity volume and degenerative valvular heart disease risk. CI, confidence interval; HR, hazard ratio; MVPA, moderate to vigorous physical activity; VHD, valvular heart disease.
资助项目China Scholarship Council[201806210439] ; China Scholarship Council[202306210379] ; Capital's Funds for Health Improvement and Research[CFH 2022-4-4037]
WOS研究方向Cardiovascular System & Cardiology
语种英语
WOS记录号WOS:001259883900001
出版者OXFORD UNIV PRESS
源URL[http://119.78.100.204/handle/2XEOYT63/39874]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Wu, Yongjian
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Dept Cardiol, Fuwai Hosp,Natl Ctr Cardiovasc Dis,State Key Lab C, Beijing, Peoples R China
2.Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Res Ctr, Quebec Heart & Lung Inst, 2725 Chemin St Foy, Quebec City, PQ G1V-4G5, Canada
3.Osaka Univ, Grad Sch Med, Dept Med Sports & Performing Arts, 2 2 Yamadaoka, Suita, Osaka 5650871, Japan
4.Univ Queensland, Inst Mol Biosci, St Lucia, QLD, Australia
5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol,Minist Hlth, Beijing, Peoples R China
6.Univ Copenhagen, Dept Math Sci, Copenhagen, Denmark
7.Chinese Acad Sci, Inst Comp Technol, Beijing, Peoples R China
8.Chinese Acad Medical Sci, Key Lab Cardiovasc Epidemiol, Dept Epidemiol, Peking Union Med Coll,State Key Lab Cardiovasc Dis, Beijing, Peoples R China
9.Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai, Peoples R China
10.Chinese Acad Med Sci, Peking Union Med Coll, Fuwai Hosp, Dept Cardiol,Natl Ctr Cardiovasc Dis, 167 Beilishi Rd, Beijing 100037, Peoples R China
推荐引用方式
GB/T 7714		 Li, Ziang,Cheng, Sijing,Guo, Bo,et al. Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis[J]. EUROPEAN HEART JOURNAL,2024:16.
APA Li, Ziang.,Cheng, Sijing.,Guo, Bo.,Ding, Lu.,Liang, Yu.,...&Wu, Yongjian.(2024).Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis.EUROPEAN HEART JOURNAL,16.
MLA Li, Ziang,et al."Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis".EUROPEAN HEART JOURNAL (2024):16.

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来源：计算技术研究所

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