Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration
文献类型：期刊论文
| 作者 | Li, Hongyi1,2; Li, Bei1; Luo, Wenqi3; Qi, Xi4; Hao, You5; Yang, Chaozhi6; Li, Wenqing1,7; Li, Jiazheng7; Hua, Zhen7; Guo, Tan8 |
| 刊名 | ISCIENCE
 |
| 出版日期 | 2024-04-19 |
| 卷号 | 27期号:4页码:22 |
| DOI | 10.1016/j.isci.2024.109407 |
| 英文摘要 | Converging studies showed interstitial fluid (ISF) adjacent to blood vessels flows in adventitia along vasculature into heart and lungs. We aim to reveal circulatory pathways and regulatory mechanism of such adventitial ISF flow in rat model. By MRI, real-time fluorescent imaging, micro -CT, and histological analysis, ISF was found to flow in adventitial matrix surrounded by fascia and along systemic vessels into heart, then flow into lungs via pulmonary arteries and back to heart via pulmonary veins, which was neither perivascular tissues nor blood or lymphatic vessels. Under physiological conditions, speckle -like adventitial ISF flow rate was positively correlated with heart rate, increased when holding breath, became pulsative during heavy breathing. During cardiac or respiratory cycle, each dilation or contraction of heart or lungs can generate to-and-fro adventitial ISF flow along femoral veins. Discovered regulatory mechanisms of adventitial ISF flow along vasculature by heart and lungs will revolutionize understanding of cardiovascular system. |
| 资助项目 | National Natural Science Foundation of China[82050004] ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-D-202202] ; Beijing Hospital Clinical Research 121 Project[121 -2016002] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001228026300001 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/40072]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Li, Hongyi; Li, Hua; Ma, Chao; Ji, Fusui |
| 作者单位 | 1.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Res Ctr Interstitial Fluid Circulat, Beijing 100730, Peoples R China 2.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Geriatr, Beijing 100730, Peoples R China 3.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Cardiac Surg, Beijing 100730, Peoples R China 4.Peking Univ, Beijing Hosp, Inst Geriatr Med, Chinese Acad Med Sci,Sch Clin Med 5, Beijing 100730, Peoples R China 5.Chinese Acad Sci, Inst Comp Technol, Beijing 100190, Peoples R China 6.China Univ Petr East China, Sch Comp Sci & Technol, Qingdao 266580, Peoples R China 7.Beijing Hosp, Inst Geriatr Med, Chinese Acad Med Sci, Natl Ctr Gerontol, Beijing 100730, Peoples R China 8.Beijing Hosp, Inst Geriatr Med, Chinese Acad Med Sci, Natl Ctr Gerontol,Dept Radiol, Beijing 100730, Peoples R China 9.Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Acupuncture, Beijing 100730, Peoples R China 10.Chinese Acad Med Sci, Beijing Hosp, Natl Ctr Gerontol Inst Geriatr Med, Dept Cardiol, Beijing 100730, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hongyi,Li, Bei,Luo, Wenqi,et al. Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration[J]. ISCIENCE,2024,27(4):22. |
| APA | Li, Hongyi.,Li, Bei.,Luo, Wenqi.,Qi, Xi.,Hao, You.,...&Ji, Fusui.(2024).Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration.ISCIENCE,27(4),22. |
| MLA | Li, Hongyi,et al."Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration".ISCIENCE 27.4(2024):22. |
入库方式： OAI收割
来源：计算技术研究所
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