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Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia

文献类型：期刊论文

作者Li, Shaobing3,4; Lu, Chenghao4; Liu, Nannan3,4; Li, Yanzhe3,4; Wang, Xinxu3,4; Li, Shen3,4; Li, Jie4; Zhang, Xiang Yang1,2
刊名SCHIZOPHRENIA RESEARCH
出版日期2024-12-01
卷号274页码:352-359
关键词Schizophrenia First-episode antipsychotic-na & iuml Suicide Event-related potential P300 Depression ve
ISSN号0920-9964
DOI10.1016/j.schres.2024.10.015
通讯作者Li, Shen(lishen@tmu.edu.cn) ; Li, Jie(jieli@tjmhc.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
英文摘要Objective: Suicidal thoughts and behaviors (STBs) are critical concern in schizophrenia (SZ). Concurrent changes in event-related potential (ERP), particularly the P300 (P3) components, have been observed in SZ patients, but the association between these changes and STBs remains unclear. This study aims to explore the relationships between P3 components and STBs in first-episode antipsychotic-na & iuml;ve SZ (FEAN-SZ) patients. Methods: The study included 321 FEAN-SZ patients and 146 healthy controls (HC). Sociodemographic data, clinical assessments, and ERP P3 components (N1, P3a, and P3b) were collected. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), while depressive symptoms were evaluated with the Hamilton Depression Scale (HAMD). Results: Compared to HC, FEAN-SZ patients exhibited lower N1 and P3 amplitudes and longer latencies (all p(s) < 0.001). Patients with STBs exhibited higher scores on negative, general psychopathology, PANSS total and HAMD, decreased N1 and P3a amplitudes, as well as prolonged P3a and P3b latencies compared to those without STBs (all p(s) < 0.001). The P3a latency predicted the general psychopathology scores ((3 = 0.103, p < 0.001), and the N1 amplitude predicted the HAMD scores ((3 = -1.057, p = 0.001), both exclusively within the STBs group. Logistic regression analysis identified that N1 amplitude (Beta = -0.132, p = 0.018, OR = 1.02, 95%CI = 1.01-1.04) and HAMD scores (Beta = 0.068, p = 0.001, OR = 1.07, 95%CI = 1.03-1.11) as independent predictors of STBs in FEAN-SZ patients. Combining these variables yielded an area under the receiver operating characteristic (AUCROC) curve of 0.840 for distinguishing between patients with and without STBs. Conclusions: FEAN-SZ patients with STBs have lower P3 amplitude and longer latency. The N1 amplitude and depressive levels are associated with STBs in FEAN-SZ patients. The N1 amplitude may serve as an early biological marker for STBs in SZ patients.
收录类别SCI
WOS关键词MAJOR DEPRESSIVE DISORDER ; RISK-FACTORS ; METAANALYSIS ; PREVALENCE ; MORTALITY ; BIOMARKER
资助项目National Natural Science Foundation of China[82371512] ; National Key Research and Development Program of China[2023YFF1203700] ; Tianjin Health Research Project[TJWJ2024MS037]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001347185600001
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; National Key Research and Development Program of China ; Tianjin Health Research Project
源URL[http://ir.psych.ac.cn/handle/311026/49261]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Li, Shen; Li, Jie; Zhang, Xiang Yang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Tianjin Med Univ, Tianjin Anding Hosp, Brain Assessment & Intervent Lab, Mental Hlth Ctr, Tianjin 300222, Peoples R China
4.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, Tianjin 300222, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shaobing,Lu, Chenghao,Liu, Nannan,et al. Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2024,274:352-359.
APA Li, Shaobing.,Lu, Chenghao.,Liu, Nannan.,Li, Yanzhe.,Wang, Xinxu.,...&Zhang, Xiang Yang.(2024).Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia.SCHIZOPHRENIA RESEARCH,274,352-359.
MLA Li, Shaobing,et al."Association between auditory P300 event-related potential and suicidal thoughts and behaviors in first-episode antipsychotic-na?ve patients with schizophrenia".SCHIZOPHRENIA RESEARCH 274(2024):352-359.

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来源：心理研究所

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