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Gender differences in clinical characteristics and influencing factors of suicide attempts in first-episode and drug-na?ve major depressive disorder patients with comorbid metabolic syndrome

文献类型：期刊论文

作者Sun, Ping7; Huang, Yingying6; Yu, Hui7; Wu, Xiaohui5; Chen, Jun5; Fang, Yiru3,4,5; Zhang, Xiangyang1,2
刊名BMC PSYCHIATRY
出版日期2024-11-11
卷号24期号:1页码:13
关键词Major depressive disorder Metabolic syndrome Suicide attempts Gender difference
DOI10.1186/s12888-024-06256-3
通讯作者Fang, Yiru(yirufang@aliyun.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要BackgroundsPatients with major depressive disorder (MDD) have a high rate of metabolic syndrome (MetS), which could worsen disease progression. One of the most serious progressions in MDD is suicide attempts (SAs). Previous studies have found gender differences in MetS and SAs among MDD patients respectively. Therefore, we aimed to explore gender differences of SAs in first-episode and drug-na & iuml;ve (FEDN) MDD patients with comorbid MetS.Methods1718 outpatients with FEDN MDD were recruited. Depression, anxiety and psychotic symptoms were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively. Blood sugar, blood fat, blood pressure and body mass index (BMI) were measured to evaluate MetS.Results34.4% patients with FEDN MDD were diagnosed as MetS and those subjects with or without MetS differed in the distribution of SAs and gender. In MetS subgroup, 29.5% and 29.7% of male and female subjects had SAs respectively, without significant differences. However, compared with non-suicide attempters, suicide attempters had higher level of blood pressure in female subjects, while there are no differences in any clinical variables in male subjects. Additionally, the influencing factors for SAs differed by gender. The HAMA scores and BMI were variables associated with SAs in male patients while HAMA scores, marital status and systolic blood pressure (SBP) were associated with SAs in female patients. Furthermore, the receiver operating characteristics (ROC) curves, demonstrating the combination all influencing factors by gender, showed good performance and model accuracy.ConclusionsIn FEDN MDD patients with comorbid MetS, there were no gender differences in SAs. However, clinical characteristics and influencing factors of SAs differed in different gender groups.
收录类别SCI
WOS关键词MENTAL-DISORDERS ; SEX-DIFFERENCES ; RATING-SCALE ; RISK-FACTORS ; PREVALENCE ; SYMPTOMS ; METAANALYSIS ; ASSOCIATION ; ANXIETY ; ADULTS
资助项目National Key R&D Program of China[2016YFC1307100] ; National Natural Science Foundation of China[81930033] ; Clinical Research Plan of Shanghai Hospital Development Center[16CR2027B] ; Science and Technology Program of Guangdong[2018B030334001]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001352865100003
出版者BMC
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Clinical Research Plan of Shanghai Hospital Development Center ; Science and Technology Program of Guangdong
源URL[http://ir.psych.ac.cn/handle/311026/49330]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Fang, Yiru; Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Shanghai Key Lab Psychot disorders, Shanghai 201108, Peoples R China
4.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Psychiat & Affect Disorders Ctr, Sch Med, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China
5.Shanghai Jiao Tong Univ, Clin Res Ctr, Shanghai Mental Hlth Ctr, Div Mood Disorders,Sch Med, Shanghai 200030, Peoples R China
6.Nanjing Univ, Nanjing Brain Hosp, Clin Teaching Hosp, Med Sch, Nanjing 210093, Peoples R China
7.Qingdao Mental Hlth Ctr, Qingdao 266034, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Ping,Huang, Yingying,Yu, Hui,et al. Gender differences in clinical characteristics and influencing factors of suicide attempts in first-episode and drug-na?ve major depressive disorder patients with comorbid metabolic syndrome[J]. BMC PSYCHIATRY,2024,24(1):13.
APA Sun, Ping.,Huang, Yingying.,Yu, Hui.,Wu, Xiaohui.,Chen, Jun.,...&Zhang, Xiangyang.(2024).Gender differences in clinical characteristics and influencing factors of suicide attempts in first-episode and drug-na?ve major depressive disorder patients with comorbid metabolic syndrome.BMC PSYCHIATRY,24(1),13.
MLA Sun, Ping,et al."Gender differences in clinical characteristics and influencing factors of suicide attempts in first-episode and drug-na?ve major depressive disorder patients with comorbid metabolic syndrome".BMC PSYCHIATRY 24.1(2024):13.

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来源：心理研究所

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