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Reduced resting-state functional connectivity of default mode network subsystems in patients with obsessive-compulsive disorder

文献类型：期刊论文

作者Guo, Qihui1,2; Zhu, Rongrong1,2; Zhou, Huixia1,2; Ma, Zheng1,2; He, Ying1,2; Wang, Dongmei1,2; Zhang, Xiangyang1,2
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2025-01-15
卷号369页码:1108-1114
关键词Resting-state functional connectivity Default mode network subsystems Obsessive-compulsive disorder Medication
ISSN号0165-0327
DOI10.1016/j.jad.2024.10.109
通讯作者Wang, Dongmei(wangdm@psych.ac.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Objectives: Neuroimaging studies have reported extensive resting-state functional connectivity (rsFC) abnormalities in the default mode network (DMN) in patients with obsessive-compulsive disorder (OCD), but findings are inconsistent. DMN can be divided into three subsystems: core, dorsal medial prefrontal cortex (dMPFC), and medial temporal lobe (MTL). This study aimed to explore abnormalities in rsFC strength within and between DMN subsystems in OCD patients, and their relationship with clinical symptoms. Methods: This study recruited 39 OCD patients and 45 healthy controls (HCs). OCD symptoms were assessed using the Yale-Brown Obsessive-Compulsive Scale (YBOCS). The seed-to-seed method was used to construct rsFC matrix. The rsFC strength within and between the three DMN subsystems were calculated. Results: Compared to the HC group, the OCD group exhibited reduced rsFC strength within core subsystem (F = 7.799, p = 0.007, Bonferroni corrected p = 0.042). Further, this reduction was also observed in the unmedicated OCD group (n = 19), but not in the medicated OCD group (n = 18). In addition, rsFC strength within core subsystem was negatively correlated with the obsession subscale of YBOCS in the OCD group (r = -0.512, p = 0.004, Bonferroni corrected p = 0.008). Further, this correlation was also significant in the unmedicated OCD group, but not in the medicated OCD group. Conclusions: Our findings suggest that reduced rsFC strength within core subsystem is a feature of OCD patients and may serve as a potential biomarker of obsession severity. Moreover, pharmacological treatments may affect rsFC strength in DMN.
收录类别SCI
WOS关键词METAANALYSIS ; MODULATION ; SCALE
资助项目Science and Technology Program of Guangzhou[2021ZD0202102] ; CAS Key Lab of Mental Health[202206060005]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001346469200001
出版者ELSEVIER
资助机构Science and Technology Program of Guangzhou ; CAS Key Lab of Mental Health
源URL[http://ir.psych.ac.cn/handle/311026/49245]  
专题心理研究所_健康与遗传心理学研究室
通讯作者Wang, Dongmei; Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Qihui,Zhu, Rongrong,Zhou, Huixia,et al. Reduced resting-state functional connectivity of default mode network subsystems in patients with obsessive-compulsive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2025,369:1108-1114.
APA Guo, Qihui.,Zhu, Rongrong.,Zhou, Huixia.,Ma, Zheng.,He, Ying.,...&Zhang, Xiangyang.(2025).Reduced resting-state functional connectivity of default mode network subsystems in patients with obsessive-compulsive disorder.JOURNAL OF AFFECTIVE DISORDERS,369,1108-1114.
MLA Guo, Qihui,et al."Reduced resting-state functional connectivity of default mode network subsystems in patients with obsessive-compulsive disorder".JOURNAL OF AFFECTIVE DISORDERS 369(2025):1108-1114.

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来源：心理研究所

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