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Concurrent oculomotor hyperactivity and deficient anti-saccade performance in obsessive-compulsive disorder

文献类型：期刊论文

作者Wang, Zhenni4,5; Zhang, Chen5; Guo, Qihui2,3; Fan, Qing1,5; Wang, Lihui1,4,5
刊名JOURNAL OF PSYCHIATRIC RESEARCH
出版日期2024-12-01
卷号180页码:402-410
关键词Obsessive-compulsive disorder (OCD) Anti-saccade Inhibitory function Oculomotor hyperactivity
ISSN号0022-3956
DOI10.1016/j.jpsychires.2024.11.013
通讯作者Fan, Qing(fanqing@smhc.org.cn) ; Wang, Lihui(lihui.wang@sjtu.edu.cn)
英文摘要Existing studies mainly focused on the inhibition of the task-interfering response to understand the inhibitory deficits of obsessive-compulsive disorder (OCD). However, recent studies suggested that inhibitory function is broadly involved in response preparation and implementation. It is yet unknown if the inhibition dysfunction in OCD extends beyond the task-interfering response to the general inhibitory function. Here we address this issue based on the multidimensional eye-movement measurements, which can better capture the inhibitory deficits than manual responses. Thirty-one OCD patients and 32 healthy controls (HCs) completed the anti-saccade task where multidimensional eye-movement features were developed. Confirmatory factor analysis (CFA) suggested two components of inhibitory function that negatively correlated with each other: one component of oculomotor hyperactivity in generating oculomotor output which is characterized with early premature saccades, early cross rates and saccade number; the other component of task-specific oculomotor efficiency which is characterized with task accuracy, saccade latency, correction rate, and amplitude gain. Importantly, OCD showed both stronger oculomotor hyperactivity and deficient oculomotor efficiency than HCs, and the machine-learning-based classifications showed that the features of oculomotor hyperactivity had higher prediction accuracy than the features of oculomotor efficiency in distinguishing OCD from HCs. Our results suggested that OCD has concurrent deficits in oculomotor hyperactivity and oculomotor efficiency, which may originate from a common inhibitory dysfunction.
收录类别SCI
WOS关键词RESPONSE-INHIBITION ; ANTISACCADE TASK ; EYE-MOVEMENTS ; NEURAL BASIS ; SCHIZOPHRENIA ; NEUROPSYCHOLOGY ; ENDOPHENOTYPE ; DEPRESSION ; CIRCUITS ; TESTS
资助项目National Natural Science Foundation of China[32271086] ; Shanghai Jiao Tong University Grant[YG2022QN108] ; Shanghai Jiao Tong University Star of Jiao Tong University medical engineering cross research fund key project[YG2021ZD28] ; General project of Shanghai Municipal Health Com-mission[202140054] ; Academic Leader of Health Discipline of Shanghai Municipal Health Commission[2022XD025]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001356343900001
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构National Natural Science Foundation of China ; Shanghai Jiao Tong University Grant ; Shanghai Jiao Tong University Star of Jiao Tong University medical engineering cross research fund key project ; General project of Shanghai Municipal Health Com-mission ; Academic Leader of Health Discipline of Shanghai Municipal Health Commission
源URL[http://ir.psych.ac.cn/handle/311026/49311]  
专题心理研究所_健康与遗传心理学研究室
通讯作者Fan, Qing; Wang, Lihui
作者单位1.Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Psychol, Huashan Rd 1954, Shanghai 200030, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Wan Ping Nan Rd 600, Shanghai 200030, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Zhenni,Zhang, Chen,Guo, Qihui,et al. Concurrent oculomotor hyperactivity and deficient anti-saccade performance in obsessive-compulsive disorder[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2024,180:402-410.
APA Wang, Zhenni,Zhang, Chen,Guo, Qihui,Fan, Qing,&Wang, Lihui.(2024).Concurrent oculomotor hyperactivity and deficient anti-saccade performance in obsessive-compulsive disorder.JOURNAL OF PSYCHIATRIC RESEARCH,180,402-410.
MLA Wang, Zhenni,et al."Concurrent oculomotor hyperactivity and deficient anti-saccade performance in obsessive-compulsive disorder".JOURNAL OF PSYCHIATRIC RESEARCH 180(2024):402-410.

入库方式： OAI收割

来源：心理研究所

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