Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade
文献类型：期刊论文
| 作者 | Li, Lei17; Ge, Zhengping16,17; Liu, Shihao17; Zheng, Kun15,17; Li, Yaqi17; Chen, Kaiqi14; Fu, Yesheng17; Lei, Xiaoguang13,14; Cui, Zeling17; Wang, Yifan17 |
| 刊名 | SCIENCE
 |
| 出版日期 | 2024-10-25 |
| 卷号 | 386期号:6720页码:13 |
| ISSN号 | 0036-8075 |
| DOI | 10.1126/science.adl0799 |
| 英文摘要 | Tardigrades are captivating organisms known for their resilience in extreme environments, including ultra-high-dose radiation, but the underlying mechanisms of this resilience remain largely unknown. Using genome, transcriptome, and proteome analysis of Hypsibius henanensis sp. nov., we explored the molecular basis contributing to radiotolerance in this organism. A putatively horizontally transferred gene, DOPA dioxygenase 1 (DODA1), responds to radiation and confers radiotolerance by synthesizing betalains-a type of plant pigment with free radical-scavenging properties. A tardigrade-specific radiation-induced disordered protein, TRID1, facilitates DNA damage repair through a mechanism involving phase separation. Two mitochondrial respiratory chain complex assembly proteins, BCS1 and NDUFB8, accumulate to accelerate nicotinamide adenine dinucleotide (NAD+) regeneration for poly(adenosine diphosphate-ribosyl)ation (PARylation) and subsequent poly(adenosine diphosphate-ribose) polymerase 1 (PARP1)-mediated DNA damage repair. These three observations expand our understanding of mechanisms of tardigrade radiotolerance. |
| WOS关键词 | HORIZONTAL GENE-TRANSFER ; SPECIES DELIMITATION ; BETALAINS ; BIOSYNTHESIS ; TRANSLOCATION ; PROTEINS ; GENOMICS ; SURVIVAL ; MICE ; TREE |
| 资助项目 | National Natural Science Foundation of China[82192881] ; National Natural Science Foundation of China[32270711] ; National Natural Science Foundation of China[22193073] ; Beijing Nova Program[20220484230] ; State Key Laboratory of Proteomics[SKLP-K202004] ; State Key Laboratory of Proteomics[SKLP-O201704] ; Beijing National Laboratory for Molecular Sciences[BNLMS-CXX-202106] ; New Cornerstone Science Foundation through the XPLORER PRIZE |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001348382900008 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 资助机构 | National Natural Science Foundation of China ; Beijing Nova Program ; State Key Laboratory of Proteomics ; Beijing National Laboratory for Molecular Sciences ; New Cornerstone Science Foundation through the XPLORER PRIZE |
| 源URL | [http://ir.idsse.ac.cn/handle/183446/11798]  |
| 专题 | 深海科学研究部_深海生物学研究室_海洋哺乳动物与海洋生物声学研究组 |
| 通讯作者 | Fan, Guangyi; Wang, Lizhi; Yang, Dong; Zhang, Lingqiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China 3.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Marine Mammal & Marine Bioacoust Lab, Sanya 572006, Peoples R China 4.Shaanxi Xueqian Normal Univ, Coll Life Sci & Food Engn, Xian 710100, Peoples R China 5.Chinese Acad Sci, Inst Zool, Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China 6.Hebei Univ, Coll Life Sci, Baoding 071000, Peoples R China 7.Tsinghua Univ, Adv Innovat Ctr Struct Biol, Beijing Frontier Res Ctr Biol Struct, Sch Life Sci,Minist Educ,Key Lab Prot Sci, Beijing 100084, Peoples R China 8.SCIEX China, Beijing 100015, Peoples R China 9.BGI Res, Qingdao 266555, Peoples R China 10.BGI Res, Shenzhen 518083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lei,Ge, Zhengping,Liu, Shihao,et al. Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade[J]. SCIENCE,2024,386(6720):13. |
| APA | Li, Lei.,Ge, Zhengping.,Liu, Shihao.,Zheng, Kun.,Li, Yaqi.,...&Zhang, Lingqiang.(2024).Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade.SCIENCE,386(6720),13. |
| MLA | Li, Lei,et al."Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade".SCIENCE 386.6720(2024):13. |
入库方式： OAI收割
来源：深海科学与工程研究所
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