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Reproductive and germ-cell mutagenic effects of poly-and perfluoroalkyl substances (PFAS) to Caenorhabditis elegans after multigenerational exposure

文献类型：期刊论文

作者Cao, Zhenxiao2,3,4; Dai, Linglong3,4,5; Li, Jiali1,3,4,6; Zhang, Jingyi7; Wang, Xialian3,4,5; Xu, An3,4; Du, Hua3,4
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2024-12-01
卷号954
关键词PFAS Multigenerational exposure Caenorhabditis elegans Germ cell mutagenicity Whole genome sequencing
ISSN号0048-9697
DOI10.1016/j.scitotenv.2024.176224
通讯作者Xu, An(anxu@ipp.ac.cn) ; Du, Hua(huadu@ipp.ac.cn)
英文摘要Per- and polyfluoroalkyl substances (PFAS) are a class of globally ubiquitous persistent organic pollutants (POPs). The developmental and reproductive toxicity of PFAS have attracted considerable attention. However, the influence of PFAS exposure on genomic stability of germ cells remains unexplored. In this study, we evaluated long-term reproductive toxicity of environmentally relevant levels of four long-chain PFAS compounds: perfluorooctanoic acid (PFOA, C8), perfluorononanoic acid (PFNA, C9), perfluorodecanoic acid (PFDA, C10), and perfluorooctanesulfonic acid (PFOS, C8), and examined their germ-cell mutagenicity in Caenorhabditis elegans. . Our findings reveal that multigenerational exposure to PFAS exhibited minor impacts on development and reproduction of worms. Among all tested PFAS, PFNA significantly increased mutation frequencies of progeny by preferentially inducing T:A -> C:G substitutions and small indels within repetitive regions. Further analysis of mutation spectra uncovered elevated frequencies of microhomology-mediated deletions and large deletions in PFOA-treated worms, indicating its potential activity in eliciting DNA double-strand breaks. This study provides the first comparative analysis of the genome-wide mutational profile of PFAS compounds, underscoring the importance of assessing germ-cell mutagenic actions of long-chain PFAS.
WOS关键词OXIDATIVE DNA-DAMAGE ; IN-VITRO ; POLYFLUOROALKYL SUBSTANCES ; PERFLUORINATED COMPOUNDS ; MUTATIONAL SIGNATURES ; C. ELEGANS ; ACIDS ; STRESS ; RISK ; CARCINOGENS
资助项目National Key Research and Development Program of China[2023YFC3708303] ; Na-tional Natural Science Foundation of China[22006149] ; Anhui Provincial Key R D Program[2022l07020021]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001332274000001
出版者ELSEVIER
资助机构National Key Research and Development Program of China ; Na-tional Natural Science Foundation of China ; Anhui Provincial Key R D Program
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/134560]  
专题中国科学院合肥物质科学研究院
通讯作者Xu, An; Du, Hua
作者单位1.Anhui Univ, Inst Informat Technol, Hefei 230601, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Anhui, Peoples R China
3.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Prov Key Lab Environm Toxicol & Pollut Contr, Hefei 230031, Anhui, Peoples R China
5.Grad Sch USTC, Sci Isl Branch, Hefei 230026, Anhui, Peoples R China
6.Anhui Univ, Inst Phys Sci, Hefei 230601, Anhui, Peoples R China
7.Anhui Med Univ, Sch Basic Med Sci, Dept Pathophysiol, 81 Mei Shan Rd, Hefei 230032, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Zhenxiao,Dai, Linglong,Li, Jiali,et al. Reproductive and germ-cell mutagenic effects of poly-and perfluoroalkyl substances (PFAS) to Caenorhabditis elegans after multigenerational exposure[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,954.
APA Cao, Zhenxiao.,Dai, Linglong.,Li, Jiali.,Zhang, Jingyi.,Wang, Xialian.,...&Du, Hua.(2024).Reproductive and germ-cell mutagenic effects of poly-and perfluoroalkyl substances (PFAS) to Caenorhabditis elegans after multigenerational exposure.SCIENCE OF THE TOTAL ENVIRONMENT,954.
MLA Cao, Zhenxiao,et al."Reproductive and germ-cell mutagenic effects of poly-and perfluoroalkyl substances (PFAS) to Caenorhabditis elegans after multigenerational exposure".SCIENCE OF THE TOTAL ENVIRONMENT 954(2024).

入库方式： OAI收割

来源：合肥物质科学研究院

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