The application of nanodiscs in membrane protein drug discovery & development and drug delivery
文献类型：期刊论文
| 作者 | Dong, Yingkui2,3; Tang, Huan4; Dai, Han2; Zhao, Hongxin2,4 ; Wang, Junfeng1,2,3
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| 刊名 | FRONTIERS IN CHEMISTRY
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| 出版日期 | 2024-09-18 |
| 卷号 | 12 |
| 关键词 | nanodisc (ND) membrane protein drug discovery & development drug delievery membrane scaffold protein (MSP) |
| ISSN号 | 2296-2646 |
| DOI | 10.3389/fchem.2024.1444801 |
| 通讯作者 | Dai, Han(daihan@hmfl.ac.cn) ; Zhao, Hongxin(zhx@hmfl.ac.cn) ; Wang, Junfeng(junfeng@hmfl.ac.cn) |
| 英文摘要 | The phospholipid bilayer nanodiscs (LNDs), as a rapidly-developing tool in recent years, provide a natural bio-memebrane environment to maintain the native conformation and functions of membrane proteins as well as a versatile delivery vehicle for a variety of hydrophobic and hydrophilic drugs. We have seen unprecedented advantages of phospholipid bilayer nanodiscs in membrane protein structure characterization, biochemical and physiological studies of membrane proteins, membrane environment studies, drug discovery & development, and drug delivery. Many previous reviews have been mainly focused on the advantages of nanodiscs in membrane protein researches, but few have touched upon the importance and potential application of nanodiscs in pharmaceutical industries. This review will provide general description of the structural characteristics, advantages, classification, and applications of phospholipid nanodiscs, with particular focus on nanodisc-enabled membrane protein drug discovery & development as well as drug delivery. |
| WOS关键词 | PHOSPHOLIPID-BILAYER NANODISCS ; NANOPARTICLES ; DETERGENT ; RECEPTOR ; SCAFFOLD ; NITRATE |
| 资助项目 | Anhui Major Basic Research Projects[2023z04020016] ; Hefei Institutes of Physical Science Director's Fund[YZJJZX202014] ; High Magnetic Field Laboratory of Anhui Province |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001330771300001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Anhui Major Basic Research Projects ; Hefei Institutes of Physical Science Director's Fund ; High Magnetic Field Laboratory of Anhui Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/134569]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Dai, Han; Zhao, Hongxin; Wang, Junfeng |
| 作者单位 | 1.Univ Sci & Technol China, Hefei, Anhui, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Anhui, Peoples R China 3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China 4.Hefei China Sci Longwood Biol Technol Co Ltd, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Yingkui,Tang, Huan,Dai, Han,et al. The application of nanodiscs in membrane protein drug discovery & development and drug delivery[J]. FRONTIERS IN CHEMISTRY,2024,12. |
| APA | Dong, Yingkui,Tang, Huan,Dai, Han,Zhao, Hongxin,&Wang, Junfeng.(2024).The application of nanodiscs in membrane protein drug discovery & development and drug delivery.FRONTIERS IN CHEMISTRY,12. |
| MLA | Dong, Yingkui,et al."The application of nanodiscs in membrane protein drug discovery & development and drug delivery".FRONTIERS IN CHEMISTRY 12(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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