On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection
文献类型：期刊论文
| 作者 | Xu, Jing1; Li, Yujin1,2; Wang, Futing2; Luo, Xinqi1; Zhang, Wei6; Lyu, Yifan2; Yang, Hongfen5; Cai, Ren2; Tan, Weihong2,3,4 |
| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2024-10-11 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/d4sc04404e |
| 通讯作者 | Cai, Ren(cairen@hnu.edu.cn) |
| 英文摘要 | A bidirectional self-powered biosensor is constructed for the quasi-simultaneous detection of Pb2+ and Hg2+ based on MoS2@CuS heterostructures as an accelerator and hybridization chain reaction (HCR) as a signal amplification strategy. MoS2@CuS heterostructures significantly facilitate electron transfer between glucose and bioelectrodes, thereby greatly improving the detection signal of self-powered biosensors. This novel biosensor employs the unique sequences of DNAzymes to isolate Pb2+ and Hg2+ by the cleavage effect and thymine (T)-Hg2+-thymine (T) structures, respectively. In the process, Pb2+ cuts the sequence of DNAzyme at the bioanode to trigger glucose oxidation to monitor Pb2+. The as-formed T-Hg2+-T structures activate HCR to reduce [Ru(NH3)6]3+ to detect Hg2+ at the biocathode. It is noteworthy that this biosensor not only realizes Pb2+ or Hg2+ detection in a single-electrode, respectively, but also can quasi-simultaneously detect both Pb2+ and Hg2+ in the bioanode and the biocathode. The novel self-powered biosensor identifies Pb2+ in the range of 106 fM to 10 fM with a limit of detection (LOD) of 3.1 fM and Hg2+ in the range of 106 fM to 1 fM with an LOD of 0.33 fM. A bidirectional self-powered biosensor is constructed for the quasi-simultaneous detection of Pb2+ and Hg2+ based on MoS2@CuS heterostructures as an accelerator and hybridization chain reaction as a signal amplification strategy. |
| WOS关键词 | SENSOR |
| 资助项目 | Natural Science Foundation of Hunan Province[235200810056] ; Joint Fund Project for Technology Research and Development Plan of Henan Technology[2024JJ5348] ; Joint Fund Project for Technology Research and Development Plan of Henan Technology[2021JJ20020] ; Hunan Provincial Natural Science Foundation of China[22004032] ; National Natural Science Foundation of China ; Dabie Mountain Laboratory, Nanhu Scholars Program for Young Scholars of XYNU |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001331184200001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | Natural Science Foundation of Hunan Province ; Joint Fund Project for Technology Research and Development Plan of Henan Technology ; Hunan Provincial Natural Science Foundation of China ; National Natural Science Foundation of China ; Dabie Mountain Laboratory, Nanhu Scholars Program for Young Scholars of XYNU |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/134579]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cai, Ren |
| 作者单位 | 1.Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Peoples R China 2.Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn, Mol Sci & Biomed Lab,State Key Lab Chemobio Sensin, Changsha 410082, Hunan, Peoples R China 3.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 4.Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Coll Chem & Chem Engn,Sch Med, Shanghai 200240, Peoples R China 5.Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China 6.Xinyang Normal Univ, Coll Life Sci, Dabie Mt Lab, Xinyang 464000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jing,Li, Yujin,Wang, Futing,et al. On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection[J]. CHEMICAL SCIENCE,2024. |
| APA | Xu, Jing.,Li, Yujin.,Wang, Futing.,Luo, Xinqi.,Zhang, Wei.,...&Tan, Weihong.(2024).On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection.CHEMICAL SCIENCE. |
| MLA | Xu, Jing,et al."On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection".CHEMICAL SCIENCE (2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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