Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells
文献类型：期刊论文
| 作者 | Zhou, Yemian1,2,3,4; Liu, Yun1,2,3 ; Wang, Tong1,2,3,4; Li, Han1,2,3,4; He, Jing1,2,3,5; Xu, An1,2,3,5
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| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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| 出版日期 | 2024-10-15 |
| 卷号 | 285 |
| 关键词 | DBPs Mutagenicity Iron homeostasis Mitochondrion Human-hamster hybrid (A(L) ) cells |
| ISSN号 | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2024.117122 |
| 通讯作者 | Xu, An(anxu@ipp.ac.cn) |
| 英文摘要 | Disinfection by-products (DBPs) generated from water treatment have serious adverse effects on human health and natural ecosystems. However, research on the mutagenicity of DBPs with different chemical structures is still limited. In the present study, we compared the mutagenicity of 8 typical DBPs in human-hamster hybrid (AL) cells and clarified the mechanisms involved. Our data displayed that the rank order for mutagenicity was as follows: iodoacetamide (IAcAm) > iodoacetonitrile (IAN) > iodoacetic acid (IAA) > bromoacetamide (BAcAm) approximate to bromoacetonitrile (BAN) > bromoacetic acid (BAA), which was confirmed by DNA double strand breaks and oxidative DNA damage. In contrast, bromoform (TBM) and iodoform (TIM) had minimal mutagenicity. The mutation spectrum analysis further revealed that IAN, IAcAm, and IAA could induce multilocus deletions in mammalian cells. Interestingly, nitrogenous DBPs (N-DBPs) and IAA were found to cause varying degrees of iron overload and lipid peroxidation, which was mediated by the activation of the Nrf2/HO-1 signaling pathway. Moreover, the presence of deferoxamine (DFO), an iron ion inhibitor, effectively reduced gamma-H2AX and 8-OHdG induced by N-DBPs and IAA. These results indicated that the variations in genotoxicity among DBPs with different structures were associated with their ability to disrupt iron homeostasis. This study provided new insights into the mechanisms underlying the structure-dependent toxicity of DBPs and established a foundation for a more comprehensive understanding and intervention of the health risks associated with DBPs. |
| WOS关键词 | CHLORINATED DRINKING-WATER ; PREGNANCY OUTCOMES ; HALOACETIC ACIDS ; DNA-DAMAGE ; CYTOTOXICITY ; TOXICITY ; GENOTOXICITY ; CANCER ; ACCUMULATION ; CONTAMINANTS |
| 资助项目 | National Key Research and Devel-opment Program of China[2023YFC3708303] ; High Magnetic Field Laboratory of Hefei Institutes of Physical Science |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001330955400001 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | National Key Research and Devel-opment Program of China ; High Magnetic Field Laboratory of Hefei Institutes of Physical Science |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/134588]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, An |
| 作者单位 | 1.Anhui Prov Key Lab Environm Toxicol & Pollut Contr, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 4.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 5.Anhui Univ, Inst Phys Sci & Informat Technol, Informat Mat & Intelligent Sensing Lab Anhui Prov, Hefei 230601, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yemian,Liu, Yun,Wang, Tong,et al. Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2024,285. |
| APA | Zhou, Yemian,Liu, Yun,Wang, Tong,Li, Han,He, Jing,&Xu, An.(2024).Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,285. |
| MLA | Zhou, Yemian,et al."Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 285(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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