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Tumor Growth Pattern and Intra- and Peritumoral Radiomics Combined for Prediction of Initial TACE Outcome in Patients with Primary Hepatocellular Carcinoma

文献类型：期刊论文

作者Li, Jiaying1; Zhou, Minhui1; Tong, Yahan1,2,3; Chen, Haibo2; Su, Ruisi1; Tao, Yinghui1; Zhang, Guodong2; Sun, Zhichao2
刊名JOURNAL OF HEPATOCELLULAR CARCINOMA
出版日期2024
卷号11
关键词hepatocellular carcinoma radiomics tumor growth pattern transarterial chemoembolization
DOI10.2147/JHC.S480554
通讯作者Tong, Yahan(sunzhichao@zcmu.edu.cn)
英文摘要Purpose: Non-invasive methods are urgently needed to assess the efficacy of transarterial chemoembolization (TACE) and to identify patients with hepatocellular carcinoma (HCC) who may benefit from this procedure. This study, therefore, aimed to investigate the predictive ability of tumor growth patterns and radiomics features from contrast-enhanced magnetic resonance imaging (CE-MRI) in predicting tumor response to TACE among patients with HCC.
Patients and Methods: A retrospective study was conducted on 133 patients with HCC who underwent TACE at three centers between January 2015 and April 2023. Enrolled patients were divided into training, testing, and validation cohorts. Rim arterial phase hyperenhancement (Rim APHE), tumor growth patterns, nonperipheral washout, markedly low apparent diffusion coefficient (ADC) value, intratumoral arteries, and clinical baseline features were documented for all patients. Radiomics features were extracted from the intratumoral and peritumoral regions across the three phases of CE-MRI. Seven prediction models were developed, and their performances were evaluated using receiver operating characteristic (ROC) and decision curve analysis (DCA).
Results: Tumor growth patterns and albumin-bilirubin (ALBI) score were significantly correlated with tumor response. Tumor growth patterns also showed a positive correlation with tumor burden (r = 0.634, P = 0.000). The Peritumor (AUC = 0.85, 0.71, and 0.77), Clinics_Peritumor (AUC = 0.86, 0.77, and 0.81), and Tumor_Peritumor (AUC = 0.87, 0.77, and 0.80) models significantly outperformed the Clinics and Tumor models (P < 0.05), while the Clinics_Tumor_Peritumor model (AUC = 0.88, 0.81, and 0.81) outperformed the Clinics (AUC = 0.67, 0.77, and 0.75), Tumor (AUC = 0.78, 0.72, and 0.68), and Clinics_Tumor (AUC = 0.82, 0.83, and 0.78) models (P < 0.05 or 0.053, respectively). The DCA curve demonstrated better predictive performance within a specific threshold probability range for Clinics_Tumor_Peritumor.
Conclusion: Combining tumor growth patterns, intra- and peri-tumoral radiomics features, and ALBI score could be a robust tool for non-invasive and personalized prediction of treatment response to TACE in patients with HCC.
WOS关键词TRANSARTERIAL CHEMOEMBOLIZATION ; PERFORMANCE ; EFFICACY ; IMPROVE ; SYSTEM
资助项目Research Project of Zhejiang Chinese Medical University[2022JKJNTZ20]
WOS研究方向Oncology
语种英语
WOS记录号WOS:001333100800001
出版者DOVE MEDICAL PRESS LTD
资助机构Research Project of Zhejiang Chinese Medical University
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/134654]  
专题中国科学院合肥物质科学研究院
通讯作者Tong, Yahan
作者单位1.Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou 310053, Peoples R China
2.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Dept Radiol, 54 Youdian Rd, Hangzhou 310006, Peoples R China
3.Univ Chinese Acad Sci, Canc Hosp, Dept Radiol, Zhejiang Canc Hosp, Hangzhou 310005, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jiaying,Zhou, Minhui,Tong, Yahan,et al. Tumor Growth Pattern and Intra- and Peritumoral Radiomics Combined for Prediction of Initial TACE Outcome in Patients with Primary Hepatocellular Carcinoma[J]. JOURNAL OF HEPATOCELLULAR CARCINOMA,2024,11.
APA Li, Jiaying.,Zhou, Minhui.,Tong, Yahan.,Chen, Haibo.,Su, Ruisi.,...&Sun, Zhichao.(2024).Tumor Growth Pattern and Intra- and Peritumoral Radiomics Combined for Prediction of Initial TACE Outcome in Patients with Primary Hepatocellular Carcinoma.JOURNAL OF HEPATOCELLULAR CARCINOMA,11.
MLA Li, Jiaying,et al."Tumor Growth Pattern and Intra- and Peritumoral Radiomics Combined for Prediction of Initial TACE Outcome in Patients with Primary Hepatocellular Carcinoma".JOURNAL OF HEPATOCELLULAR CARCINOMA 11(2024).

入库方式： OAI收割

来源：合肥物质科学研究院

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