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Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells

文献类型：期刊论文

作者Hazawa, Masaharu1,2,3,4; Ikliptikawati, Dini Kurnia2; Iwashima, Yuki4; Lin, De-Chen5; Jiang, Yuan6,7; Qiu, Yujia3; Makiyama, Kei8; Matsumoto, Koki8; Kobayashi, Akiko2; Nishide, Goro3
刊名CELL CHEMICAL BIOLOGY
出版日期2024-04-18
卷号31
ISSN号2451-9456
DOI10.1016/j.chembiol.2023.10.005
通讯作者Hazawa, Masaharu(masaharu.akj@gmail.com) ; Wong, Richard W.(rwong@staff.kanazawa-u.ac.jp)
英文摘要Master transcription factors such as TP63 establish super-enhancers (SEs) to drive core transcriptional networks in cancer cells, yet the spatiotemporal regulation of SEs within the nucleus remains unknown. The nuclear pore complex (NPC) may tether SEs to the nuclear pore where RNA export rates are maximal. Here, we report that NUP153, a component of the NPC, anchors SEs to the NPC and enhances TP63 expression by maximizing mRNA export. This anchoring is mediated through protein-protein interaction between the intrinsically disordered regions (IDRs) of NUP153 and the coactivator BRD4. Silencing of NUP153 excludes SEs from the nuclear periphery, decreases TP63 expression, impairs cellular growth, and induces epidermal differentiation of squamous cell carcinoma. Overall, this work reveals the critical roles of NUP153 IDRs in the regulation of SE localization, thus providing insights into a new layer of gene regulation at the epigenomic and spatial level.
WOS关键词MESSENGER-RNA EXPORT ; NUCLEOPORIN NUP153 ; PHASE-SEPARATION ; COMPLEX PROTEIN ; GENE-REGULATION ; TRANSCRIPTION ; ARCHITECTURE ; TRANSPORT ; PLAYS ; DIFFERENTIATION
资助项目Infiniti ; Japan Society for the Promotion of Science[17K16332] ; Japan Society for the Promotion of Science[20K07568] ; Japan Society for the Promotion of Science[23H02853] ; Japan Society for the Promotion of Science[22H02209] ; AMED[JP23kk0305026] ; Uehara Memorial Foundation ; Nakatomi Foundation ; Life Science Foundation of Japan
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:001300649500001
出版者CELL PRESS
资助机构Infiniti ; Japan Society for the Promotion of Science ; AMED ; Uehara Memorial Foundation ; Nakatomi Foundation ; Life Science Foundation of Japan
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/134878]  
专题中国科学院合肥物质科学研究院
通讯作者Hazawa, Masaharu; Wong, Richard W.
作者单位1.Kanazawa Univ, Inst Sci & Engn, Fac Biol Sci & Technol, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan
2.Kanazawa Univ, Inst Frontier Sci Initiat, Innovat Integrated Biores Core, Cell Bion Res Unit, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan
3.Kanazawa Univ, WPI Nano Life Sci Inst, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan
4.Kanazawa Univ, Inst Sci & Engn, Sch Nat Syst, Lab Mol Cell Biol, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan
5.Univ Southern Calif, Ctr Craniofacial Mol Biol, Norris Comprehens Canc Ctr, Herman Ostrow Sch Dent, Los Angeles, CA USA
6.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei 230031, Peoples R China
7.Univ Sci & Technol China, Hefei 230026, Peoples R China
8.Kanazawa Univ, Grad Sch Frontier Sci Initiat, Div Transdisciplinary Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan
9.Hirosaki Univ, Grad Sch Hlth Sci, Dept Radiat Sci, Hirosaki, Aomori 0368564, Japan
10.Kanazawa Univ, Canc Res Inst, Div Translat & Clin Oncol, Takara Machi, Kanazawa, Ishikawa 9208640, Japan
推荐引用方式
GB/T 7714		 Hazawa, Masaharu,Ikliptikawati, Dini Kurnia,Iwashima, Yuki,et al. Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells[J]. CELL CHEMICAL BIOLOGY,2024,31.
APA Hazawa, Masaharu.,Ikliptikawati, Dini Kurnia.,Iwashima, Yuki.,Lin, De-Chen.,Jiang, Yuan.,...&Wong, Richard W..(2024).Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells.CELL CHEMICAL BIOLOGY,31.
MLA Hazawa, Masaharu,et al."Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells".CELL CHEMICAL BIOLOGY 31(2024).

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来源：合肥物质科学研究院

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