中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma

文献类型：期刊论文

作者Zhang, Peng2,3,4; Tao, Changjuan5,6; Lu, Ye4; Li, Peijing5,6; Wang, Xing1; Dai, Yujie7; Xi, Yun8; Shimura, Takaya9; Li, Xinfang7; Fang, Jianmin10
刊名ADVANCED SCIENCE
出版日期2024-08-01
卷号11
关键词antibody drug conjugate decitabine ICAM1 melanoma targeted therapy
DOI10.1002/advs.202400203
通讯作者Zhang, Peng(zhangpeng2295@zjcc.org.cn) ; Yang, Liu(yangliu@hmc.edu.cn) ; He, Dawei(hedawei@hospital.cqmu.edu.cn) ; Guo, Peng(guopeng@ucas.ac.cn)
英文摘要Therapeutic benefits and underlying biomechanism(s) of antibody drug conjugates (ADC) in combination with other targeted therapeutics are largely unknown. Here, the synergy between ADC and epigenetic drug decitabine (DAC), a clinically approved DNA methylation inhibitor, in multiple preclinical models of melanoma specifically investigated. Mechanistically, the underlying biomechanisms of how DAC cooperatively worked with ICAM1 antibody conjugated DNA topoisomerase I inhibitor DXd (I1-DXd) is elucidated. DAC treatment significantly enhanced anti-tumor efficacy of I1-DXd by upregulating antigen expression, enhancing antibody internalization and potentiating tumor sensitivity by epigenetically reprogramming of melanoma. Meanwhile, I1-DXd/DAC combination also exerted regulatory effects on tumor microenvironment (TME) by enhancing tumor infiltration of innate and adaptive immune cells and improving penetration of ADCs with a boosted antitumor immunity. This study provides a rational ADC combination strategy for solid tumor treatment.
WOS关键词PHASE-I ; METASTATIC MELANOMA ; CANCER ; DNA ; EXPRESSION ; DECITABINE ; IMMUNOTHERAPY ; METHYLATION ; PROFILES ; TARGETS
资助项目National Key R&D Program of China[2023YFC3404003] ; National Natural Science Foundation of China[82172598] ; National Natural Science Foundation of China[82373782] ; Natural Science Foundation of Zhejiang Province, China[Q24H160113] ; Natural Science Foundation of Zhejiang Province, China[LZ22H310001] ; 551 Health Talent Training Project of Health Commission of Zhejiang Province, China ; Agricultural and Social Development Research Project of Hangzhou Muncipal Science and Technology Bureau[2022ZDSJ0474] ; Medical and Health Science and Technology Project of Zhejiang Province, China[2023RC134] ; Wujieping Science Foundation of China[320.6750.19094-46] ; Qiantang Interdisciplinary Research Grant
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001291158600054
出版者WILEY
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Zhejiang Province, China ; 551 Health Talent Training Project of Health Commission of Zhejiang Province, China ; Agricultural and Social Development Research Project of Hangzhou Muncipal Science and Technology Bureau ; Medical and Health Science and Technology Project of Zhejiang Province, China ; Wujieping Science Foundation of China ; Qiantang Interdisciplinary Research Grant
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/134984]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Peng; Yang, Liu; He, Dawei; Guo, Peng
作者单位1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Head & Neck Surg, Hangzhou 310022, Zhejiang, Peoples R China
2.Zhejiang Prov Peoples Hosp, Dept Med Oncol, Hangzhou 310022, Zhejiang, Peoples R China
3.Zhejiang Prov Peoples Hosp, Key Lab TumorMolecular Diag & Individualized Med, Peoples Hosp Hangzhou Med Coll, Hangzhou 310014, Zhejiang, Peoples R China
4.Chinese Acad Sci, Hangzhou Inst Med HIM, Hangzhou 310022, Zhejiang, Peoples R China
5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Radiat Oncol, Hangzhou 310022, Zhejiang, Peoples R China
6.Zhejiang Canc Hosp, Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou 310022, Zhejiang, Peoples R China
7.MabPlex Int, Yantai 264006, Shandong, Peoples R China
8.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Pathol, Hangzhou 310022, Zhejiang, Peoples R China
9.Nagoya City Univ, Grad Sch Med Sci, Dept Gastroenterol & Metab, Nagoya 4678601, Japan
10.Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Peng,Tao, Changjuan,Lu, Ye,et al. Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma[J]. ADVANCED SCIENCE,2024,11.
APA Zhang, Peng.,Tao, Changjuan.,Lu, Ye.,Li, Peijing.,Wang, Xing.,...&Guo, Peng.(2024).Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma.ADVANCED SCIENCE,11.
MLA Zhang, Peng,et al."Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma".ADVANCED SCIENCE 11(2024).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。