Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes
文献类型：期刊论文
| 作者 | Wang, Ying1,5; Feng, Chuanlin1,5; Yu, Biao2,5 ; Wang, Junjun5; Chen, Weili3,5; Song, Chao5; Ji, Xinmiao1,5; Guo, Ruowen1,5; Cheng, Guofeng1,5; Chen, Hanxiao1,5
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| 刊名 | RESEARCH
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| 出版日期 | 2024-09-05 |
| 卷号 | 7 |
| ISSN号 | 2096-5168 |
| DOI | 10.34133/research.0468 |
| 通讯作者 | Zhang, Xin(xinzhang@hmfl.ac.cn) |
| 英文摘要 | Intermittent fasting (IF) is a convenient dietary intervention for multiple diseases, including type 2 diabetes. However, whether it can be used as a long-term antidiabetic approach is still unknown. Here, we confirm that IF alone is beneficial for both moderate and severe diabetic mice, but its antidiabetic effects clearly diminish at later stages, especially for severe diabetic db/db mice, which have obviously impaired autophagy. We found that static magnetic fields can directly promote actin assembly and boost IF-induced autophagy. Consequently, the pancreatic islet and liver were improved, and the antidiabetic effects of IF were boosted. In fact, at later stages, combined static magnetic field and IF could reduce the blood glucose level of moderate type 2 diabetic mice by 40.5% (P < 0.001) and severe type 2 diabetes by 34.4% (P < 0.05), when IF alone no longer has significant blood glucose reduction effects. Therefore, although IF is generally beneficial for diabetes, our data reveal its insufficiency for late-stage diabetes, which can be compensated by a simple, noninvasive, long-lasting, and nonpharmacological strategy for effective long-term diabetic control. |
| WOS关键词 | AUTOPHAGY ; ACTIN |
| 资助项目 | National Key R&D Program of China[2023YFB3507004] ; National Natural Science Foundation of China[U21A20148] ; National Natural Science Foundation of China[52377228] ; International Partnership Program of Chinese Academy of Sciences[116134- KYSB20210052] ; Heye Health Technology Chong Ming Project[HYCMP2021010] ; CASHIPS Director's Fund[BJPY2021A06] ; Collaborative Innovation Program of Hefei Science Center, CAS[2022HSC-CIP002] ; CAS Project for Young Scientists in Basic Research[YSBR-097] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001313999800001 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; International Partnership Program of Chinese Academy of Sciences ; Heye Health Technology Chong Ming Project ; CASHIPS Director's Fund ; Collaborative Innovation Program of Hefei Science Center, CAS ; CAS Project for Young Scientists in Basic Research |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/135230]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Univ Sci & Technol China, Sci Isl Branch, Grad Sch, Hefei, Anhui, Peoples R China 2.Anhui Med Univ, NHC Key Lab Study Abnormal Gametes & Reprod Tract, Hefei, Anhui, Peoples R China 3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China 4.Univ Dundee, Sch Life Sci, Med Res Council MRC, Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland 5.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ying,Feng, Chuanlin,Yu, Biao,et al. Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes[J]. RESEARCH,2024,7. |
| APA | Wang, Ying.,Feng, Chuanlin.,Yu, Biao.,Wang, Junjun.,Chen, Weili.,...&Zhang, Xin.(2024).Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes.RESEARCH,7. |
| MLA | Wang, Ying,et al."Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes".RESEARCH 7(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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