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A study on the determination of the metabolites of 2,4,6-Trinitrotoluene using a dual-drift tube ion mobility spectrometer

文献类型：期刊论文

作者Zhang, Xu1,2; Luo, Yuanjiang1,2; Xia, Lei2; Song, Yu2; Li, Wanjun2; Kong, Lingwen1,2; Liu, Yawei2; Shen, Chengyin2; Huang, Chaoqun2; Chu, Yannan2
刊名TALANTA
出版日期2025
卷号281
关键词TNT Metabolites Ion mobility spectrometry Dual-drift tube
ISSN号0039-9140
DOI10.1016/j.talanta.2024.126857
通讯作者Xia, Lei(lxia@cmpt.ac.cn) ; Huang, Chaoqun(cqhuang@aiofm.ac.cn)
英文摘要2,4,6-Trinitrotoluene (TNT) and its four metabolites, namely 2-ADNT, 4-ADNT, 2,4-DANT, and 2,6-DANT, are highly toxic substances. These metabolites also serve as biomarkers for assessing the health of individuals exposed to TNT. In this study, a homemade DDT-IMS apparatus was utilized to detect these metabolites. Under negative detection mode, the drift times of 2-ADNT and 4-ADNT showed subtle shifts within a drift tube temperature range of 100 C-degrees-120 C-degrees, aiding in their differentiation. In positive detection mode for 2,4-DANT and 2,6-DANT, significant variations were observed in both the number and drift time of their positive product ions across a drift tube temperature range of 80 C-degrees-120 C-degrees. Consequently, optimal analytical performance for these metabolites was achieved at approximately 100 C-degrees. Evaluation of the instrumental response during the measurement of the four metabolites in both positive and negative modes revealed that negative detection mode offered greater advantages of detecting these compounds. The working ranges for measuring the four metabolites spanned two orders of magnitude, with detection limits for each metabolite nearly below 1 ng. Notably, clear identification of the signals for these metabolites was achieved even when samples were mixed in urine, highlighting the ability of the DDT-IMS in detecting TNT metabolites. The developed DDT-IMS detection method has significant potential for enhancing environmental risk assessment and biological hazard evaluation, particularly in relation to human exposure to TNT.
WOS关键词URINARY METABOLITES ; GAS-CHROMATOGRAPHY ; HEMOGLOBIN ADDUCTS ; EXPLOSIVES ; TEMPERATURE
资助项目National Natural Science Foundation of China[62171433] ; National Natural Science Foundation of China[22073100] ; National Natural Science Foundation of China[22076190] ; National Natural Science Foundation of China[22376198] ; National Natural Science Foundation of China[22306187] ; HFIPS Director's Fund[YZJJ202305-CX] ; HFIPS Director's Fund[YZJJ202405-TS] ; HFIPS Director's Fund[BJPY2021B08] ; Anhui Provincial Key R D Program[2022a05020034] ; Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument[2023BMP05]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001312167500001
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; HFIPS Director's Fund ; Anhui Provincial Key R D Program ; Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/135272]  
专题中国科学院合肥物质科学研究院
通讯作者Xia, Lei; Huang, Chaoqun
作者单位1.Univ Sci & Technol China, Hefei 230026, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xu,Luo, Yuanjiang,Xia, Lei,et al. A study on the determination of the metabolites of 2,4,6-Trinitrotoluene using a dual-drift tube ion mobility spectrometer[J]. TALANTA,2025,281.
APA Zhang, Xu.,Luo, Yuanjiang.,Xia, Lei.,Song, Yu.,Li, Wanjun.,...&Chu, Yannan.(2025).A study on the determination of the metabolites of 2,4,6-Trinitrotoluene using a dual-drift tube ion mobility spectrometer.TALANTA,281.
MLA Zhang, Xu,et al."A study on the determination of the metabolites of 2,4,6-Trinitrotoluene using a dual-drift tube ion mobility spectrometer".TALANTA 281(2025).

入库方式： OAI收割

来源：合肥物质科学研究院

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