Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF
文献类型：期刊论文
| 作者 | Zhang, Fenglin5; Cui, Xueling3,6; Yang, Ke1 ; Guo, Rui5; Zhu, Linjing3; Zhao, Wei2,6; Liu, Zhonghui5,6; Liu, Boyang3,4
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| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
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| 出版日期 | 2024-12-05 |
| 卷号 | 142 |
| 关键词 | Lung adenocarcinoma Cell migration Activin A EGF ERK1/2 signaling Microfluidic device |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2024.113170 |
| 通讯作者 | Liu, Boyang(zhonghui@jlu.edu.cn) |
| 英文摘要 | Activin A, a member of the transforming growth factor (3 (TGF-(3) superfamily, is involved in tumorigenesis and tumor progression. However, it remains unclear whether activin A can affect the migration of lung adenocarcinoma (LUAD) cells. In this study, the results of differentially expressed genes (DEGs) identification revealed that lung adenocarcinoma tissues exhibited lower expression of activin (3A mRNA, but higher expression of epidermal growth factor (EGF) and MMP9 mRNA compared to nontumor tissues. Moreover, we found that activin A inhibited human LUAD A549 cell proliferation promoted by EGF. Additionally, EGF induced A549 cell migration in microfluidic device, while activin A attenuated EGF actions. Simultaneously, EGF increased the levels of migration-related proteins, but activin A played the opposite role. Furthermore, the study revealed that EGF upregulated the ratio of p-ERK/ERK in A549 cells, which was weakened by activin A, and A549 cell migration regulated by activin A was not related to calcium signaling. In addition, the inhibitory effect of activin A on EGF-induced A549 cell migration was attenuated by the ERK inhibitor FR180204. These findings demonstrate that activin A effectively hinders the migration of A549 cells induced by EGF through ERK1/2 signaling, suggesting that targeting activin A may hold promise in the treatment of EGF-dependent LUAD growth and metastasis. |
| WOS关键词 | FAMILY |
| 资助项目 | Foundation of Science and Tech-nology Department of Jilin Province[20190201037JC] ; Foundation of Science and Tech-nology Department of Jilin Province[20220402079GH] ; Foundation of Science and Tech-nology Department of Jilin Province[20230505042ZP] ; Norman Bethune Medical Projects[2018B05] |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001317795500001 |
| 出版者 | ELSEVIER |
| 资助机构 | Foundation of Science and Tech-nology Department of Jilin Province ; Norman Bethune Medical Projects |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/135395]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Liu, Boyang |
| 作者单位 | 1.Chinese Acad Sci, Inst Appl Technol, Hefei Inst Phys Sci, Hefei 230031, Anhui Province, Peoples R China 2.Jilin Univ, Dept Internal Med, Hosp 1, Changchun 130021, Jilin Province, Peoples R China 3.Jilin Univ, Coll Basic Med Sci, Dept Genet, Changchun 130021, Jilin Province, Peoples R China 4.Jilin Jianzhu Univ, Dept Sci Res, Changchun 130118, Jilin Province, Peoples R China 5.Jilin Univ, Coll Basic Med Sci, Dept Immunol, Changchun 130021, Jilin Province, Peoples R China 6.Key Lab Neuroimmunol & Clin Immunol Jilin Prov, Changchun 130021, Jilin Province, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Fenglin,Cui, Xueling,Yang, Ke,et al. Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2024,142. |
| APA | Zhang, Fenglin.,Cui, Xueling.,Yang, Ke.,Guo, Rui.,Zhu, Linjing.,...&Liu, Boyang.(2024).Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF.INTERNATIONAL IMMUNOPHARMACOLOGY,142. |
| MLA | Zhang, Fenglin,et al."Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF".INTERNATIONAL IMMUNOPHARMACOLOGY 142(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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