ALOX5 induces EMT and promotes cell metastasis via the LTB4/BLT2/ PI3K/AKT pathway in ovarian cancer
文献类型：期刊论文
| 作者 | Ji, Zhaodong3; Li, Xiaoqi1,2; Gao, Wen4; Xia, Qiuyi3; Li, Jiwei5 |
| 刊名 | CELLULAR SIGNALLING
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 124 |
| 关键词 | ALOX5 Metastasis EMT Ovarian cancer |
| ISSN号 | 0898-6568 |
| DOI | 10.1016/j.cellsig.2024.111404 |
| 通讯作者 | Ji, Zhaodong(zdji18@fudan.edu.cn) ; Li, Jiwei(lijiwei2021@csu.edu.cn) |
| 英文摘要 | Ovarian cancer represents the most lethal gynecological malignancy with high invasiveness. Epithelial-tomesenchymal transition (EMT) plays a critical role in cancer metastasis. However, the role of ALOX5 in EMT and cancer metastasis in ovarian cancer (OC) remain unclear. In this study, ALOX5 was significantly upregulated in tumorous and metastatic tissue compared with normal tissue. Furthermore, we found that overexpression of ALOX5 promoted cell migration and invasion, while silencing of ALOX5 suppressed migration and invasion in OC cell lines. Mechanistically, we found that enhanced expression of ALOX5 promoted EMT and cancer metastasis through activation of the PI3K/AKT pathway, whereas SNAIl inhibited the transcription of CDH1 in OC cells. Taken together, our results highlight a role for the ALOX5/PI3K/AKT/ SNAI1 axis in OC, which provides novel strategies for the prevention of metastasis in OC. |
| WOS关键词 | PANCREATIC-CANCER ; 5-LIPOXYGENASE ; BLT2 ; EXPRESSION ; INVOLVEMENT ; INHIBITION ; TARGET |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001316069400001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/135449]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Ji, Zhaodong; Li, Jiwei |
| 作者单位 | 1.Fudan Univ, Shanghai Canc Ctr, Dept Gynecol Oncol, Shanghai 200032, Peoples R China 2.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 3.Fudan Univ, Huashan Hosp, Dept Lab Med, Shanghai 200040, Peoples R China 4.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 5.Cent South Univ, Xiangya Hosp 2, Dept Oncol, Changsha, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Zhaodong,Li, Xiaoqi,Gao, Wen,et al. ALOX5 induces EMT and promotes cell metastasis via the LTB4/BLT2/ PI3K/AKT pathway in ovarian cancer[J]. CELLULAR SIGNALLING,2024,124. |
| APA | Ji, Zhaodong,Li, Xiaoqi,Gao, Wen,Xia, Qiuyi,&Li, Jiwei.(2024).ALOX5 induces EMT and promotes cell metastasis via the LTB4/BLT2/ PI3K/AKT pathway in ovarian cancer.CELLULAR SIGNALLING,124. |
| MLA | Ji, Zhaodong,et al."ALOX5 induces EMT and promotes cell metastasis via the LTB4/BLT2/ PI3K/AKT pathway in ovarian cancer".CELLULAR SIGNALLING 124(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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