Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium
文献类型：期刊论文
| 作者 | Wei, Xin2,3; Wang, Dan3,4; Xu, Ziming3,5; Liu, Jiajia3,4; Zhu, Qizhi2,3; Chen, Qi2; Tang, Heng6; Xu, Weiping1,2,3,4 |
| 刊名 | HELIYON
 |
| 出版日期 | 2024-09-30 |
| 卷号 | 10 |
| 关键词 | Dendrobium Chemical composition Pharmacological mechanism Dendrobium polysaccharides |
| DOI | 10.1016/j.heliyon.2024.e37541 |
| 通讯作者 | Tang, Heng(tangheng@mail.ustc.edu.cn) ; Xu, Weiping(weipingx@ustc.edu.cn) |
| 英文摘要 | Dendrobium is a precious Chinese herbal medicine, which belongs to the genus Orchidaceae. Ancient records and modern pharmacological research show that Dendrobium has pharmacological effects such as anti-tumor, antioxidant regulating immunity and blood glucose, and antiaging. Dendrobium contains polysaccharides, alkaloids, bibenzyl, sesquiterpenes, phenanthrene, polyphenols and other types of chemicals. Its pharmacological activity is closely related to these chemical components. For example, dendrobium extracts can achieve anti-tumor effects by inhibiting tumor cell proliferation and metastasis, promoting cell apoptosis and ferroptosis, or increasing cell sensitivity to chemotherapy drugs. It enhances immunity by regulating immune cell activity or cytokine release. In addition, it can alleviate neurodegenerative diseases by protecting nerve cells from apoptotic damage. In recent years, research reports on biologically active compounds in Dendrobium have shown a blowout growth, which makes us realize that it is meaningful to continuously update the research progress on the components and pharmacological regulatory mechanism of this traditional Chinese medicine. By classifying the collected chemical components according to different chemical structures and summarizing their pharmacological mechanisms, we investigated the current research progress of Dendrobium and provide a more comprehensive scientific foundation for the further development and clinical transformation of Dendrobium in the future. |
| WOS关键词 | ISCHEMIA-REPERFUSION INJURY ; NOBILE LINDL. ALKALOIDS ; IN-VITRO ; SESQUITERPENE GLYCOSIDES ; CANCER CELLS ; STRUCTURAL-CHARACTERIZATION ; BIBENZYL DERIVATIVES ; INHIBITS MIGRATION ; GUT MICROBIOTA ; PHENANTHRENE |
| 资助项目 | National Natural Science Foundation of China[52072360] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001320010700001 |
| 出版者 | CELL PRESS |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/135565]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Tang, Heng; Xu, Weiping |
| 作者单位 | 1.Key Lab Tumor Immunotherapy & Nutr Therapy, Hefei, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machines, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Peoples R China 4.Univ Sci & Technol China, Affiliated Hosp USTC 1, Gerontol Inst Anhui Prov, Dept Geriatr,Div Life Sci & Med, Hefei 230001, Peoples R China 5.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Ophthalmol, Hefei 230001, Peoples R China 6.Wanbei Coal Elect Grp Gen Hosp, Suzhou 234011, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Xin,Wang, Dan,Xu, Ziming,et al. Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium[J]. HELIYON,2024,10. |
| APA | Wei, Xin.,Wang, Dan.,Xu, Ziming.,Liu, Jiajia.,Zhu, Qizhi.,...&Xu, Weiping.(2024).Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium.HELIYON,10. |
| MLA | Wei, Xin,et al."Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium".HELIYON 10(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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