A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease
文献类型：期刊论文
| 作者 | Li, Kai Xin1,2,3,4,5; Fan, Lei1,3,4,5; Wang, Hongjuan3,4,5; Tian, Yushan3,4,5; Zhang, Sen6; Hu, Qingyuan1,2,3,4,5; Liu, Fanglin1,2,3,4,5 ; Chen, Huan3,4,5; Hou, Hongwei3,4,5
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| 刊名 | FRONTIERS IN MOLECULAR NEUROSCIENCE
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| 出版日期 | 2024-09-18 |
| 卷号 | 17 |
| 关键词 | Maoa EcoRV polymorphism Monoamine oxidase A synonymous mutation rs1137070 mouse model |
| ISSN号 | 1662-5099 |
| DOI | 10.3389/fnmol.2024.1406708 |
| 通讯作者 | Liu, Fanglin(flliu@ipp.ac.cn) ; Chen, Huan(hunny_ch@163.com) ; Hou, Hongwei(qsfctc@163.com) |
| 英文摘要 | The Monoamine Oxidase-A (MAOA) EcoRV polymorphism (rs1137070) is a unique synonymous mutation (c.1409 T > C) within the MAOA gene, which plays a crucial role in Maoa gene expression and function. This study aimed to explore the relationship between the mouse Maoa rs1137070 genotype and differences in MAOA gene expression. Mice carrying the CC genotype of rs1137070 exhibited a significantly lower Maoa expression level, with an odds ratio of 2.44 compared to the T carriers. Moreover, the wild-type TT genotype of MAOA demonstrated elevated mRNA expression and a longer half-life. We also delved into the significant expression and structural disparities among genotypes. Furthermore, it was evident that different aspartic acid synonymous codons within Maoa influenced both MAOA expression and enzyme activity, highlighting the association between rs1137070 and MAOA. To substantiate these findings, a dual-luciferase reporter assay confirmed that GAC was more efficient than GAT binding. Conversely, the synonymous mutation altered Maoa gene expression in individual mice. An RNA pull-down assay suggested that this alteration could impact the interaction with RNA-binding proteins. In summary, our results illustrate that synonymous mutations can indeed regulate the downregulation of gene expression, leading to changes in MAOA function and their potential association with neurological-related diseases. |
| WOS关键词 | CODON USAGE INFLUENCES ; MONOAMINE-OXIDASE ; PROTEIN-STRUCTURE ; ELONGATION ; OPTIMALITY ; RESPONSES ; BEHAVIOR ; ROLES |
| 资助项目 | Provincial and Ministerial Major Project of China[110202101018 (XX-04)] ; Provincial and Ministerial Major Project of China[110202102014] ; Provincial and Ministerial Major Project of China[552022AK0070] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001326815800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Provincial and Ministerial Major Project of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/135809]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Liu, Fanglin; Chen, Huan; Hou, Hongwei |
| 作者单位 | 1.Chinese Acad Sci, Inst Tech Biol & Agr Engn, Hefei Inst Phys Sci, Hefei, Peoples R China 2.Univ Sci & Technol China, Div Life Sci & Med, Hefei, Peoples R China 3.China Natl Tobacco Qual Supervis & Test Ctr, Zhengzhou, Peoples R China 4.Key Lab Tobacco Biol Effects, Zhengzhou, Peoples R China 5.Beijing Life Sci Acad, Beijing, Peoples R China 6.Northwest Univ, Sch Chem Engn, Dept Bioengn, Xian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Kai Xin,Fan, Lei,Wang, Hongjuan,et al. A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2024,17. |
| APA | Li, Kai Xin.,Fan, Lei.,Wang, Hongjuan.,Tian, Yushan.,Zhang, Sen.,...&Hou, Hongwei.(2024).A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease.FRONTIERS IN MOLECULAR NEUROSCIENCE,17. |
| MLA | Li, Kai Xin,et al."A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease".FRONTIERS IN MOLECULAR NEUROSCIENCE 17(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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