A Simple Binary Supramolecular Co-Assembly Platform for Enhanced Tumor Imaging and Therapy
文献类型：期刊论文
| 作者 | Huang, Yifan2,3,4; Chen, Cheng3; Yu, Zian3; Cao, Wei5; Peng, Shengjie5; Zhang, Guangtao2; Zhang, Qianzijing1; Zhang, Guozhen1; Jiang, Jun3; Yuan, Yue2,3 |
| 刊名 | SMALL
 |
| 出版日期 | 2024-08-25 |
| 关键词 | co-assembly nanocarriers short peptide derivatives tumor imaging tumor therapy |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.202402763 |
| 通讯作者 | Yuan, Yue(yueyuan@ustc.edu.cn) |
| 英文摘要 | The primary challenges in tumor imaging and therapy revolve around improving targeting efficiency, enhancing probe/drug delivery efficacy, and minimizing off-target signals and toxicity. Although various carriers have been developed, many are difficult to synthesize, costly, and not universally applicable. Furthermore, numerous carriers exhibit limited delivery rates in solid tumors, particularly larger nanocarriers. To address these challenges, a simple binary co-assembly drug delivery platform has been designed using the readily synthesized small molecule Cys(SEt)-Lys-CBT (CKCBT) as the self-assembly building block. CKCBT can effectively penetrate tumor cells due to its positively charged Lys side chain and small size. Upon glutathione reduction, CKCBT co-assembles with Nile red or Chlorin e6 to form nanofibers inside tumor cells. This enables their specific accumulation in tumor cells rather than normal cells and extends their exposure time, resulting in precise and enhanced tumor imaging and treatment. Hence, this uncomplicated and highly efficient binary co-assembly drug delivery platform can be easily adapted to a broad spectrum of probes and drugs, presenting a novel approach for advancing clinical diagnosis and therapy. A Simple Binary Supramolecular Co-assembly Platform: A simple GSH-responsive binary co-assembly drug delivery platform to increase the concentration and exposure time of NR/Ce6 within tumor cells, thereby improving tumor imaging and therapeutic efficacy is developed. This simple and highly efficient platform can be adapted to a broad spectrum of probes and drugs, providing a new approach to advancing clinical diagnosis and therapy. image |
| WOS关键词 | BIOCOMPATIBLE CONDENSATION REACTION ; NANOSTRUCTURES ; NANOCARRIERS |
| 资助项目 | National Key R&D Program of China[2022YFA1305100] ; National Natural Science Foundation of China[22175168] ; Fundamental Research Funds for the Central Universities[WK9990000116] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001297237700001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/135854]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yuan, Yue |
| 作者单位 | 1.Univ Sci & Technol China, Hefei Natl Res Ctr Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China 2.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Neurosurg, Div Life Sci & Med, Hefei 230031, Anhui, Peoples R China 3.Univ Sci & Technol China, Key Lab Precis & Intelligent Chem, Hefei 230026, Anhui, Peoples R China 4.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Radiat Oncol, Div Life Sci & Med, Hefei 230031, Anhui, Peoples R China 5.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yifan,Chen, Cheng,Yu, Zian,et al. A Simple Binary Supramolecular Co-Assembly Platform for Enhanced Tumor Imaging and Therapy[J]. SMALL,2024. |
| APA | Huang, Yifan.,Chen, Cheng.,Yu, Zian.,Cao, Wei.,Peng, Shengjie.,...&Yuan, Yue.(2024).A Simple Binary Supramolecular Co-Assembly Platform for Enhanced Tumor Imaging and Therapy.SMALL. |
| MLA | Huang, Yifan,et al."A Simple Binary Supramolecular Co-Assembly Platform for Enhanced Tumor Imaging and Therapy".SMALL (2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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