NIR-II Responsive Fe-Doped Carbon Nanoparticles for Photothermal-Enhanced Chemodynamic Synergistic Oncotherapy
文献类型：期刊论文
| 作者 | Wang, Xingyu2,3; Song, Tianwei4,5; Wu, Xianli1,3; Lin, Yefeng2,3; Shi, Xinyi2,3; Qian, Junchao2,4 ; Nie, Rongrong6; Wang, Hui2,3
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2024-08-22 |
| 卷号 | 16 |
| 关键词 | Fe doping carbon nanoparticles NIR-II response photothermaltherapy chemodynamic therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.4c09215 |
| 通讯作者 | Qian, Junchao(qianjunchao@hmfl.ac.cn) ; Nie, Rongrong(nrr63@nju.edu.cn) ; Wang, Hui(hw39@hmfl.ac.cn) |
| 英文摘要 | Phototherapy has demonstrated substantial development because in the second near-infrared (NIR-II) window it has a larger tissue penetration and fewer adverse consequences. In this work, a particular kind of NIR-II responsive Fe-doped carbon nanoparticles (FDCNs) is synthesized using a one-pot hydrothermal method for combined photothermal and chemodynamic therapy. The mesoporous nanostructure of FDCN, which has a size distribution that exceeds 225 nm, allows for effective acidification. The iron ions released from these nanoparticles can catalyze the decomposition of hydrogen peroxide (H2O2) into hydroxyl radical (center dot OH) for chemodynamic therapy (CDT). In addition to their CDT utility, FDCN can effectively adsorb and transform 1064 nm light into local heat, achieving a photothermal conversion efficacy (PCE) of 36.3%. This dual functionality not only allows for the direct eradication of cancer cells through photothermal therapy (PTT) but also enhances the chemodynamic reaction, creating a synergistic effect that amplifies the therapeutic outcome. The FDCN has demonstrated remarkable anticancer activity in both cellular and animal tests without incurring major systemic toxicity. This suggests that the compound has great promise for use in clinical cancer therapy. |
| WOS关键词 | THERAPY |
| 资助项目 | National Key R&D Program of China[2021YFA1600202] ; National Natural Science Foundation of China[U2032162] ; Hefei Institutes of Physical Science Director's Fund[BJPY2021B06] ; Collaborative Innovation Program of Hefei Science Center of CAS[2022HSC-CIP013] ; High Magnetic Field Laboratory of Anhui Province[AHHM-FX-2021-04] ; Anhui Provincial Natural Science Foundation[2308085J18] ; Anhui Provincial Natural Science Foundation[2208085J10] ; Medical Science and Technology Development Foundation of Nanjing Department of Health[ZKX23057] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001296680600001 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Hefei Institutes of Physical Science Director's Fund ; Collaborative Innovation Program of Hefei Science Center of CAS ; High Magnetic Field Laboratory of Anhui Province ; Anhui Provincial Natural Science Foundation ; Medical Science and Technology Development Foundation of Nanjing Department of Health |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/135905]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Qian, Junchao; Nie, Rongrong; Wang, Hui |
| 作者单位 | 1.Anhui Med Univ, Sch Basic Med, Dept Pathol & Pathophysiol, Hefei 230032, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 4.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol,Hefei Canc H, Hefei 230031, Anhui, Peoples R China 5.Binzhou Med Univ, Sch Med Imaging, Yantai 264003, Peoples R China 6.Nanjing Univ, Med Sch, Nanjing Stomatol Hosp, Nanjing 210008, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xingyu,Song, Tianwei,Wu, Xianli,et al. NIR-II Responsive Fe-Doped Carbon Nanoparticles for Photothermal-Enhanced Chemodynamic Synergistic Oncotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2024,16. |
| APA | Wang, Xingyu.,Song, Tianwei.,Wu, Xianli.,Lin, Yefeng.,Shi, Xinyi.,...&Wang, Hui.(2024).NIR-II Responsive Fe-Doped Carbon Nanoparticles for Photothermal-Enhanced Chemodynamic Synergistic Oncotherapy.ACS APPLIED MATERIALS & INTERFACES,16. |
| MLA | Wang, Xingyu,et al."NIR-II Responsive Fe-Doped Carbon Nanoparticles for Photothermal-Enhanced Chemodynamic Synergistic Oncotherapy".ACS APPLIED MATERIALS & INTERFACES 16(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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