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Microbial conversion of ethanol to high-value products: progress and challenges

文献类型：期刊论文

作者Sun, Manman2,3,4,5; Gao, Alex Xiong1; Liu, Xiuxia6; Bai, Zhonghu6; Wang, Peng2,3; Ledesma-Amaro, Rodrigo4,5
刊名BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS
出版日期2024-08-19
卷号17
关键词Renewable carbon source Ethanol Biomanufacturing Sustainability Acetyl-CoA Ethanol metabolism Stress response
DOI10.1186/s13068-024-02546-w
通讯作者Bai, Zhonghu(baizhonghu@jiangnan.edu.cn) ; Wang, Peng(pengwang@ipp.ac.cn) ; Ledesma-Amaro, Rodrigo(r.ledesma-amaro@imperial.ac.uk)
英文摘要Industrial biotechnology heavily relies on the microbial conversion of carbohydrate substrates derived from sugar- or starch-rich crops. This dependency poses significant challenges in the face of a rising population and food scarcity. Consequently, exploring renewable, non-competing carbon sources for sustainable bioprocessing becomes increasingly important. Ethanol, a key C2 feedstock, presents a promising alternative, especially for producing acetyl-CoA derivatives. In this review, we offer an in-depth analysis of ethanol's potential as an alternative carbon source, summarizing its distinctive characteristics when utilized by microbes, microbial ethanol metabolism pathway, and microbial responses and tolerance mechanisms to ethanol stress. We provide an update on recent progress in ethanol-based biomanufacturing and ethanol biosynthesis, discuss current challenges, and outline potential research directions to guide future advancements in this field. The insights presented here could serve as valuable theoretical support for researchers and industry professionals seeking to harness ethanol's potential for the production of high-value products. Highlights the characteristics of ethanol as a carbon source in bioprocessing.Summarizes microbial ethanol metabolism, stress responses, and tolerance mechanisms.Reviews recent progress in ethanol-based biomanufacturing and ethanol biosynthesis.
WOS关键词ALCOHOL-DEHYDROGENASE ; SACCHAROMYCES-CEREVISIAE ; ESCHERICHIA-COLI ; CORYNEBACTERIUM-GLUTAMICUM ; ASPERGILLUS-NIDULANS ; GENE ; PSEUDOMONAS ; TOLERANCE ; STRESS ; ACID
资助项目the National Key Research and Development Program of China[22378167] ; the National Key Research and Development Program of China[22078128] ; the National Key Research and Development Program of China[21938004] ; the National Key Research and Development Program of China[12375352] ; National Natural Science Foundation of China[2308085MC76] ; Anhui Provincial Natural Science Foundation[2023YFC3402400] ; National Key Research and Development Program of China[202103a06020003] ; Major Projects of Science and Technology of Anhui Province[JUSRP221032] ; Fundamental Research Funds for the Central Universities[BB/T013176/1] ; BBSRC[DEUSBIO-949080] ; European Research Council (ERC)
WOS研究方向Biotechnology & Applied Microbiology ; Energy & Fuels
语种英语
WOS记录号WOS:001293669700001
出版者BMC
资助机构the National Key Research and Development Program of China ; National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation ; National Key Research and Development Program of China ; Major Projects of Science and Technology of Anhui Province ; Fundamental Research Funds for the Central Universities ; BBSRC ; European Research Council (ERC)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/136085]  
专题中国科学院合肥物质科学研究院
通讯作者Bai, Zhonghu; Wang, Peng; Ledesma-Amaro, Rodrigo
作者单位1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong 999077, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
3.Inst Hefei Artificial Intelligence Breeding Accele, Hefei 230000, Peoples R China
4.Imperial Coll London, Dept Bioengn, London SW7 2AZ, England
5.Imperial Coll London, Imperial Coll, Ctr Synthet Biol, London SW7 2AZ, England
6.Jiangnan Univ, Natl Engn Res Ctr Cereal Fermentat & Food Biomfg, Wuxi 214112, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Manman,Gao, Alex Xiong,Liu, Xiuxia,et al. Microbial conversion of ethanol to high-value products: progress and challenges[J]. BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS,2024,17.
APA Sun, Manman,Gao, Alex Xiong,Liu, Xiuxia,Bai, Zhonghu,Wang, Peng,&Ledesma-Amaro, Rodrigo.(2024).Microbial conversion of ethanol to high-value products: progress and challenges.BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS,17.
MLA Sun, Manman,et al."Microbial conversion of ethanol to high-value products: progress and challenges".BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS 17(2024).

入库方式： OAI收割

来源：合肥物质科学研究院

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