Subtyping of gastric cancer based on basement membrane genes that stratifies the prognosis, immune infiltration and therapeutic response
文献类型：期刊论文
| 作者 | Tang, Xin1,5; Liu, Yu1,5; Zhao, Jiarong2; Fu, Changfang3,4; Yang, Wulin1,5 |
| 刊名 | DISCOVER ONCOLOGY
 |
| 出版日期 | 2024-08-20 |
| 卷号 | 15 |
| 关键词 | Basement membrane Gastric cancer Metastasis Molecular classification Pathology |
| DOI | 10.1007/s12672-024-01238-z |
| 通讯作者 | Fu, Changfang(fcf1998@ustc.edu.cn) ; Yang, Wulin(yangw@cmpt.ac.cn) |
| 英文摘要 | Gastric cancer (GC) is highly heterogeneous and prone to metastasis, which are obstacles to the effectiveness of treatment. The basement membrane (BM) acts as a barrier to tumor cell invasion and metastasis. It is critical to investigate the relationship between BM status, metastasis, and patient prognosis. In several large cohorts, we investigated BM gene expression-based molecular classification and risk-prognosis models for GC, examined tumor microenvironment (TME) differences among different molecular subtypes, and developed risk models in predicting prognosis, immunotherapy effectiveness, and chemotherapy resistance. Three GC subtypes (BMclusterA/B/C) based on BM gene expression status were discovered. Each of the three GC subtypes has unique immune infiltration and activated oncogenic signals. Moreover, a 6-gene score (BMscore) predictive model was developed. The low BMscore group had a high tumor mutation burden, high immunogenicity, and low RHOJ expression levels, implying that individuals with GC in this category may be more susceptible to immunotherapy and treatment. The EMT subtype showed a considerably higher BMscore than the other subtypes in the Asian Organization for Research on Cancer (ACRG) molecular classification. Endothelial cells, smooth muscle cells, and fibroblasts may be engaged in regulating BM reorganization in GC progression, according to single-cell transcriptome analyses. In conclusion, we defined a novel molecular classification of GC based on BM genes, developed a prognostic risk model, and elucidated the cell subpopulations involved in BM remodeling at the single-cell level. This study has deepened the understanding of the relationship between GC metastasis and BM alterations, achieved prognostic stratification, and guided therapy. |
| WOS关键词 | MATRICES |
| 资助项目 | Pharmaceutical Research and Exploration Fund |
| WOS研究方向 | Oncology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:001295033100001 |
| 出版者 | SPRINGER |
| 资助机构 | Pharmaceutical Research and Exploration Fund |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/136100]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Fu, Changfang; Yang, Wulin |
| 作者单位 | 1.Grad Sch Univ Sci & Technol China, Sci Isl Branch, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Hefei Canc Hosp, Med Pathol Ctr, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Pharm, Div Life Sci & Med, Hefei 230001, Peoples R China 4.Anhui Prov Key Lab Precis Pharmaceut Preparat & Cl, Hefei 230001, Anhui, Peoples R China 5.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Xin,Liu, Yu,Zhao, Jiarong,et al. Subtyping of gastric cancer based on basement membrane genes that stratifies the prognosis, immune infiltration and therapeutic response[J]. DISCOVER ONCOLOGY,2024,15. |
| APA | Tang, Xin,Liu, Yu,Zhao, Jiarong,Fu, Changfang,&Yang, Wulin.(2024).Subtyping of gastric cancer based on basement membrane genes that stratifies the prognosis, immune infiltration and therapeutic response.DISCOVER ONCOLOGY,15. |
| MLA | Tang, Xin,et al."Subtyping of gastric cancer based on basement membrane genes that stratifies the prognosis, immune infiltration and therapeutic response".DISCOVER ONCOLOGY 15(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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