Dual endogenous stimulus-responsive Fe3O4@enzymes@ZIF-8 nanocomposites promote enzymatic circulation chemotherapy
文献类型：期刊论文
| 作者 | Zhou, Xuezhi1,2; Wu, Zhaoguo1,2; Wang, Jin2 ; Zhao, Aiwu2
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| 刊名 | NEW JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2024-06-24 |
| 卷号 | 48 |
| ISSN号 | 1144-0546 |
| DOI | 10.1039/d4nj00660g |
| 通讯作者 | Wang, Jin(jwang@iim.ac.cn) ; Zhao, Aiwu(awzhao@iim.ac.cn) |
| 英文摘要 | An APTES-functionalized magnetic core-immobilized enzyme drives the formation of an acid-sensitive ZIF-8 shell via biomineralization growth, which offers a spontaneous dual-endogenous stimulus-responsive modal enzyme catalytic-chemotherapy for HeLa tumor cells. Herein, the ZIF-8 shell plays a dual role in the combination therapy, i.e., protecting activities of embedded enzymes and loading therapeutic agents into the framework. In order to enhance the efficiency of enzyme therapy, a biocascade reaction in confined space via two types of embedded enzymes under endogenous glucose stimuli was performed, which promotes continuous consumption of endogenous glucose, leading to starvation of tumor cells. Simultaneously, the inherent acidic tumor microenvironment and gluconic acid produced from endogenous glucose oxidation can gradually dissociate the ZIF-8 shell with the aid of pH-stimulus-responsive mode to enhance endo-lysosomal escape for releasing therapeutic agents to effectively induce apoptosis of tumor cells. The recovery of the magnetic core can regenerate multifunctional nanoplatforms for achieving circulation therapy of tumor cells. |
| WOS关键词 | NANOPARTICLES ; NANOCARRIERS ; THERAPY ; DESIGN |
| 资助项目 | National Natural Science Foundation of China[U1732122] ; National Natural Science Foundation of China[61875255] ; National Natural Science Foundation of China |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001244241100001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/136185]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Jin; Zhao, Aiwu |
| 作者单位 | 1.Grad Sch Univ Sci & Technol China, Sci Isl Branch, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Inst Solid State Phys, HeFei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Xuezhi,Wu, Zhaoguo,Wang, Jin,et al. Dual endogenous stimulus-responsive Fe3O4@enzymes@ZIF-8 nanocomposites promote enzymatic circulation chemotherapy[J]. NEW JOURNAL OF CHEMISTRY,2024,48. |
| APA | Zhou, Xuezhi,Wu, Zhaoguo,Wang, Jin,&Zhao, Aiwu.(2024).Dual endogenous stimulus-responsive Fe3O4@enzymes@ZIF-8 nanocomposites promote enzymatic circulation chemotherapy.NEW JOURNAL OF CHEMISTRY,48. |
| MLA | Zhou, Xuezhi,et al."Dual endogenous stimulus-responsive Fe3O4@enzymes@ZIF-8 nanocomposites promote enzymatic circulation chemotherapy".NEW JOURNAL OF CHEMISTRY 48(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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