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Symmetrically Fluorinated D-π-A Structured Cyanine Dye for Highly Efficient NIR-II Imaging-Guided Cancer Phototheranostics

文献类型：期刊论文

作者Hassan, Muhammad3; Su, Yi Tan4; Iqbal, Sania Zafar2; Nawaz, Raziq1; Wang, Yucai3,4; Jiang, Wei3
刊名SMALL
出版日期2024-06-22
关键词cancer phototheranostics donor-pi-acceptor structure NIR-II fluorophore vessel imaging
ISSN号1613-6810
DOI10.1002/smll.202401905
通讯作者Wang, Yucai(yucaiwang@ustc.edu.cn) ; Jiang, Wei(jwustc@ustc.edu.cn)
英文摘要Near-infrared-II (NIR-II) fluorescence imaging-guided photothermal therapy (PTT) represents a cutting-edge approach for precise tumor diagnosis and treatment, providing real-time therapeutic efficacy evaluation. However, a significant challenge lies in the creation of phototheranostic agents that provide robust imaging and efficient photothermal conversion. To address this, a donor-pi-acceptor (D-pi-A) structure heptamethine cyanine derivative, IR1116, that confers a strong intramolecular charge transfer effect is developed. To enhance its applicability, IR1116 is formulated with DSPE-PEG to create a water-dispersible NIR-II phototheranostic nanoheater, NPIR1116. This nanoheater benefits from the incorporation of an electron-withdrawing group, leading to reduced photooxidation activity and significantly improved photostability. NPIR1116 exhibits strong NIR-II absorption and fluorescence, peaking at 1004 and 1116 nm, respectively, as well as a photothermal conversion efficiency of 79% under 1064 nm lasers. In vitro and in vivo studies showed the efficacy of NPIR1116 in tumor imaging via NIR-II fluorescence and its ability to effectively induce tumor cell apoptosis under 1064 nm laser irradiation. These findings underscore the potential of NPIR1116 in NIR-II fluorescence imaging-guided PTT for tumor treatment, paving the way for further advancements in NIR-II dye development and bioimaging technologies.
WOS关键词FLUOROPHORES
资助项目National Key R&D Program of China ; Strategic Priority Research Pro-gram of the Chinese Academy of Sciences[XDB0490000] ; National Natural Science Foundation of China[52025036] ; National Natural Science Foundation of China[52273156] ; Anhui Provincial Key Re-search and Development Project[2023s07020019] ; Anhui Provincial Major Science and Technology Project[202303a07020010] ; University Synergy Innovation Program of Anhui Province[GXXT-2022-060] ; Anhui Province Natural Science Foundation[2308085Y01] ; [2022YFC2303700]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:001252365200001
出版者WILEY-V C H VERLAG GMBH
资助机构National Key R&D Program of China ; Strategic Priority Research Pro-gram of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; Anhui Provincial Key Re-search and Development Project ; Anhui Provincial Major Science and Technology Project ; University Synergy Innovation Program of Anhui Province ; Anhui Province Natural Science Foundation
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/136406]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Yucai; Jiang, Wei
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machines, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China
3.Univ Sci & Technol China, Affiliated Hosp 1, Dept Radiol, Div Life Sci & Med, Hefei 230001, Peoples R China
4.Hefei Comprehens Natl Sci Ctr, Inst Hlth & Med, Ctr Adv Interdisciplinary Sci & Biomed IHM, Hefei 230601, Peoples R China
推荐引用方式
GB/T 7714		 Hassan, Muhammad,Su, Yi Tan,Iqbal, Sania Zafar,et al. Symmetrically Fluorinated D-π-A Structured Cyanine Dye for Highly Efficient NIR-II Imaging-Guided Cancer Phototheranostics[J]. SMALL,2024.
APA Hassan, Muhammad,Su, Yi Tan,Iqbal, Sania Zafar,Nawaz, Raziq,Wang, Yucai,&Jiang, Wei.(2024).Symmetrically Fluorinated D-π-A Structured Cyanine Dye for Highly Efficient NIR-II Imaging-Guided Cancer Phototheranostics.SMALL.
MLA Hassan, Muhammad,et al."Symmetrically Fluorinated D-π-A Structured Cyanine Dye for Highly Efficient NIR-II Imaging-Guided Cancer Phototheranostics".SMALL (2024).

入库方式： OAI收割

来源：合肥物质科学研究院

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