Understanding the role of DNA methylation in colorectal cancer: Mechanisms, detection, and clinical significance
文献类型：期刊论文
| 作者 | Zhao, Ningning3,4; Lai, Chuanxi1; Wang, Yunfei2; Dai, Sheng1; Gu, Hongcang3,4 |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
 |
| 出版日期 | 2024-05-01 |
| 卷号 | 1879 |
| 关键词 | Colorectal cancer (CRC) DNA methylation (DNAm) CpG islands (CGIs) Mechanisms Clinical application |
| ISSN号 | 0304-419X |
| DOI | 10.1016/j.bbcan.2024.189096 |
| 通讯作者 | Dai, Sheng(daimd@zju.edu.cn) ; Gu, Hongcang(gu_hongcang@cmpt.ac.cn) |
| 英文摘要 | Colorectal cancer (CRC) is one of the deadliest malignancies worldwide, ranking third in incidence and second in mortality. Remarkably, early stage localized CRC has a 5-year survival rate of over 90%; in stark contrast, the corresponding 5-year survival rate for metastatic CRC (mCRC) is only 14%. Compounding this problem is the staggering lack of effective therapeutic strategies. Beyond genetic mutations, which have been identified as critical instigators of CRC initiation and progression, the importance of epigenetic modifications, particularly DNA methylation (DNAm), cannot be underestimated, given that DNAm can be used for diagnosis, treatment monitoring and prognostic evaluation. This review addresses the intricate mechanisms governing aberrant DNAm in CRC and its profound impact on critical oncogenic pathways. In addition, a comprehensive review of the various techniques used to detect DNAm alterations in CRC is provided, along with an exploration of the clinical utility of cancer-specific DNAm alterations. |
| WOS关键词 | COLON-CANCER ; METHYLTRANSFERASE INHIBITORS ; PROMOTER METHYLATION ; CPG-ISLANDS ; STEM-CELLS ; EPIGENETIC INACTIVATION ; TUMOR-SUPPRESSOR ; FECAL DNA ; GENOME ; PHENOTYPE |
| 资助项目 | National Natural Science Foundation of China[81703076] ; Key Research and Development Program of Zhejiang[2022C03032] ; CASHIPS seed grant |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:001245012400001 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; Key Research and Development Program of Zhejiang ; CASHIPS seed grant |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/136454]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Dai, Sheng; Gu, Hongcang |
| 作者单位 | 1.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Div Colorectal Surg, Hangzhou 310016, Zhejiang, Peoples R China 2.Zhejiang ShengTing Biotech Ltd, Hangzhou 310000, Peoples R China 3.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ningning,Lai, Chuanxi,Wang, Yunfei,et al. Understanding the role of DNA methylation in colorectal cancer: Mechanisms, detection, and clinical significance[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,2024,1879. |
| APA | Zhao, Ningning,Lai, Chuanxi,Wang, Yunfei,Dai, Sheng,&Gu, Hongcang.(2024).Understanding the role of DNA methylation in colorectal cancer: Mechanisms, detection, and clinical significance.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER,1879. |
| MLA | Zhao, Ningning,et al."Understanding the role of DNA methylation in colorectal cancer: Mechanisms, detection, and clinical significance".BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1879(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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