Design and synthesis of a new pyrazole-naphthalene Schiff base: Al3+recognition, DNA binding studies and theoretical calculations
文献类型：期刊论文
| 作者 | Pang, Yanling1; Long, Xinshu1; Jin, Xiaomin1; Meng, Desu1; Duan, Shengxia1,3; Liu, Jian2; Li, Jiaxing3
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| 刊名 | JOURNAL OF MOLECULAR STRUCTURE
 |
| 出版日期 | 2024-12-05 |
| 卷号 | 1317 |
| 关键词 | Schiff base Fluorescent sensor DNA Molecular docking Al3+ |
| ISSN号 | 0022-2860 |
| DOI | 10.1016/j.molstruc.2024.139095 |
| 通讯作者 | Duan, Shengxia(sxduan@ipp.ac.cn) ; Liu, Jian(liujian61@hezeu.edu.cn) |
| 英文摘要 | Herin, a Schiff base (L) based on 2-hydroxy-1-naphthaldehyde and 3-amino-4-pyrazolecarboxylic acid ethyl ester was successfully designed, synthesized and characterized. Spectroscopic experiments demonstrated that L can selectively recognize Al3+ with fluorescence, exhibiting a detection limit (DL) of 4.2 x 10-8 mol/L, significantly lower than that of previously reported Schiff base fluorescent sensors. The Job's plot analysis demonstrated the 1:1 stoichiometry between the Al3+ and L, with bright blue fluorescence observed under 365 nm ultraviolet light irradiation. The recognition mechanism involves the coordination of Al3+ ions with two oxygen atoms originating from the carboxylate and phenol groups, as well as the nitrogen atom of the imine moiety in Schiff bases. Additionally, the interaction nature between L and Zebra fish DNA (zf-DNA) was found to be intercalation and minor groove based on both spectroscopic method and theoretical docking study. Furthermore, the main interaction force between L and DNA was hydrophobic with a spontaneous process based on the fluorescence spectra obtained at different temperatures, which can also be attributed to static quenching. Above all, this Schiff base could be used to detect Al3+ ions in the environmental system with high accuracy. This study is also expected to contribute to the understanding of the binding mode of this type of complex to DNA, proposing a novel approach for development and creation of versatile sensors, and investigating new anticancer agents, modifying or detecting bio-molecules. |
| WOS关键词 | SELECTIVE DETECTION ; FLUORESCENT SENSOR ; AL3+ ; PROBE ; DIARYLETHENE ; CHEMOSENSOR ; RECOGNITION ; COMPLEXES ; ZN(II) ; ESIPT |
| 资助项目 | Natural Foundation of Shandong Province[ZR2021QB109] ; Key Research and Devel- opment Program of Shandong Province[2021SFGC1205] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001262878100001 |
| 出版者 | ELSEVIER |
| 资助机构 | Natural Foundation of Shandong Province ; Key Research and Devel- opment Program of Shandong Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/136677]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Duan, Shengxia; Liu, Jian |
| 作者单位 | 1.Heze Univ, Dept Chem & Chem Engn, Heze 274500, Peoples R China 2.Heze Univ, Sch Agr & Bioengn, Heze 274500, Peoples R China 3.Chinese Acad Sci, Inst Plasma Phys, CAS Key Lab Photovolta & Energy Conservat Mat, POB 1126, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pang, Yanling,Long, Xinshu,Jin, Xiaomin,et al. Design and synthesis of a new pyrazole-naphthalene Schiff base: Al3+recognition, DNA binding studies and theoretical calculations[J]. JOURNAL OF MOLECULAR STRUCTURE,2024,1317. |
| APA | Pang, Yanling.,Long, Xinshu.,Jin, Xiaomin.,Meng, Desu.,Duan, Shengxia.,...&Li, Jiaxing.(2024).Design and synthesis of a new pyrazole-naphthalene Schiff base: Al3+recognition, DNA binding studies and theoretical calculations.JOURNAL OF MOLECULAR STRUCTURE,1317. |
| MLA | Pang, Yanling,et al."Design and synthesis of a new pyrazole-naphthalene Schiff base: Al3+recognition, DNA binding studies and theoretical calculations".JOURNAL OF MOLECULAR STRUCTURE 1317(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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