Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma
文献类型：期刊论文
| 作者 | Niu, Wanxiang1,3; Yu, Huihan1,2; Fan, Xiaoqing1,3; Li, Shuyang1,2; Sun, Suling1,3; Gong, Meiting1,2; Zhang, Siyu1,3; Bi, Wenxu1,3; Chen, Xueran1,3; Fang, Zhiyou1,3 |
| 刊名 | CELLULAR SIGNALLING
 |
| 出版日期 | 2024-08-01 |
| 卷号 | 120 |
| 关键词 | Stemness-related transcription factor Glioma treatment Prognosis prediction Antitumor effect |
| ISSN号 | 0898-6568 |
| DOI | 10.1016/j.cellsig.2024.111231 |
| 通讯作者 | Chen, Xueran(xueranchen@cmpt.ac.cn) ; Fang, Zhiyou(z.fang@cmpt.ac.cn) |
| 英文摘要 | Glioma is a highly invasive and aggressive type of brain cancer with poor treatment response. Stemness-related transcription factors form a regulatory network that sustains the malignant phenotype of gliomas. We conducted an integrated analysis of stemness-related transcription factors using The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) datasets, established the characteristics of stemness-related transcription factors, including Octamer-Binding Protein 4 (OCT4), Meis Homeobox 1 (MEIS1), E2F Transcription Factor 1 (E2F1), Transcription Factor CP2 Like 1 (TFCP2L1), and RUNX Family Transcription Factor 1 (RUNX1). The characteristic of stemness-related transcription factors was identified as an independent prognostic factor for glioma patients. Patients in the high-risk group have a worse prognosis than those in the low-risk group. The glioma microenvironment in the high-risk group exhibited a more active immune status. Single-cell level analysis revealed that stem cell-like cells exhibited stronger intercellular communication than glioma cells. Meanwhile, patients in different risk stratification exhibited varying sensitivities to immunotherapy and small molecule drug therapy. XMD8-85 was more effective in the high-risk group, and its antitumor effects were validated both in vivo and in vitro. Our results indicate that this prognostic feature will assist clinicians in predicting the prognosis of glioma patients, guiding immunotherapy and personalized treatment, as well as the potential clinical application of XMD8-85 in glioma treatment, and helping to develop effective treatment strategies. |
| WOS关键词 | CANCER ; PROGRESSION |
| 资助项目 | National Natural Science Foun-dation of China[82172663] ; National Natural Science Foun-dation of China[82104208] ; National Natural Science Foun-dation of China[81872066] ; National Natural Science Foun-dation of China[81773131] ; National Natural Science Foun-dation of China[81972635] ; Innovative Program of the Devel-opment Foundation of the Hefei Center for Physical Science and Tech-nology[2021HSC-CIP011] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001264109000001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 资助机构 | National Natural Science Foun-dation of China ; Innovative Program of the Devel-opment Foundation of the Hefei Center for Physical Science and Tech-nology |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/136680]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Xueran; Fang, Zhiyou |
| 作者单位 | 1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China 2.Anhui Med Univ, Sch Basic Med Sci, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China 3.Grad Sch Univ Sci & Technol China, Sci Isl Branch, Grad Sch, 96 Jin Zhai Rd, Hefei 230026, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, Wanxiang,Yu, Huihan,Fan, Xiaoqing,et al. Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma[J]. CELLULAR SIGNALLING,2024,120. |
| APA | Niu, Wanxiang.,Yu, Huihan.,Fan, Xiaoqing.,Li, Shuyang.,Sun, Suling.,...&Fang, Zhiyou.(2024).Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma.CELLULAR SIGNALLING,120. |
| MLA | Niu, Wanxiang,et al."Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma".CELLULAR SIGNALLING 120(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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