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Nickel atom-clusters nanozyme for boosting ferroptosis tumor therapy

文献类型：期刊论文

作者Liu, Hongji1,4; Yu, Biao4; Zhou, Can2,3; Deng, Zhiming1; Wang, Hui4; Zhang, Xin4; Wang, Kai1
刊名MATERIALS TODAY BIO
出版日期2024-08-01
卷号27
关键词Ni-based nanozyme Single -atom -metal -clusters Ferroptosis Tumor therapy
ISSN号2590-0064
DOI10.1016/j.mtbio.2024.101137
通讯作者Wang, Hui(hw39@hmfl.ac.cn) ; Zhang, Xin(xinzhang@hmfl.ac.cn) ; Wang, Kai(hyxj0309@163.com)
英文摘要The translation of Fe-based agents for ferroptosis tumor therapy is restricted by the unstable iron valence state, the harsh catalytic environment, and the complex tumor self-protection mechanism. Herein, we developed a stable nickel-based single-atom-metal-clusters (NSAMCs) biocatalyst for efficient tumor ferroptosis therapy. NSAMCs with a nanowire-like nanostructure and hydrophilic functional groups exhibit good water-solubility, colloidal stability, negligible systemic toxicity, and target specificity. In particular, NSAMCs possess excellent peroxidase-like and glutathione oxidase-like activities through the synergistic influence between metal clusters and single atoms. The dual-enzymatic performance enables NSAMCs to synergistically promote efficient ferroptosis of cancer cells through lipid peroxidization aggregation and glutathione peroxidase 4 inactivation. Importantly, NSAMCs highlight the boost of ferroptosis tumor therapy via the synergistic effect between singleatoms and metal clusters, providing a practical and feasible paradigm for further improving the efficiency of ferroptosis tumor treatment.
WOS关键词QUANTUM DOTS
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:001261237000001
出版者ELSEVIER
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/136735]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Hui; Zhang, Xin; Wang, Kai
作者单位1.Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
2.Clin Res Ctr Reprod & Genet Hunan Prov, Changsha, Hunan, Peoples R China
3.Reprod & Genet Hosp CITIC Xiangya, Changsha, Hunan, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Hongji,Yu, Biao,Zhou, Can,et al. Nickel atom-clusters nanozyme for boosting ferroptosis tumor therapy[J]. MATERIALS TODAY BIO,2024,27.
APA Liu, Hongji.,Yu, Biao.,Zhou, Can.,Deng, Zhiming.,Wang, Hui.,...&Wang, Kai.(2024).Nickel atom-clusters nanozyme for boosting ferroptosis tumor therapy.MATERIALS TODAY BIO,27.
MLA Liu, Hongji,et al."Nickel atom-clusters nanozyme for boosting ferroptosis tumor therapy".MATERIALS TODAY BIO 27(2024).

入库方式： OAI收割

来源：合肥物质科学研究院

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