Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells
文献类型：期刊论文
| 作者 | Peng, Xing-Rong1,2; Liu, Jie-Qing1; Han, Zhong-Hui1,3; Yuan, Xiao-Xi1,2; Luo, Huai-Rong1,2 ; Qiu, Ming-Hua1,2
|
| 刊名 | FOOD CHEMISTRY
 |
| 出版日期 | 2013-11-15 |
| 卷号 | 141期号:2页码:920-926 |
| 关键词 | Ganoderma resinaceum Ganoderma triterpenoids Hepatoprotective activities CYP3A4 HepG2 cells |
| ISSN号 | 0308-8146 |
| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China. ; mhchiu@mail.kib.ac.cn |
| 英文摘要 | Ganoderma resinaceum Boud. (Polyporeseae) has long been used for antioxidant, immunoregulation and liver protection. From the fruiting bodies of G. resinaceum, eight new lanostanoids, lucidones D-G (1-4), 7-oxo-ganoderic acid Z(2) (5), 7-oxo-ganoderic acid Z(3) (6), ganoderesin A (7), and ganoderesin B (8), together with six known lanostanoids (9-14) were isolated. The structures of new compounds were elucidated through extensive spectroscopic analysis. In an in vitro model, ganoderesin B (8), ganoderol B (10) and lucidone A (11) showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC). However, compounds 8, 10 and 11 displayed no anti-oxidant activities by DPPH assay. Mean-while, activation for PXR (Pregnane X Receptor) of ganoderesin B (8), ganoderol B (10) and lucidone A (11) was evaluated; ganoderol (10) exhibited a vital activation for PXR-induced CYP3A4 expression. These results suggested that GTs (Ganoderma triterpenoids) exhibited hepatoprotective activities by lowering ALT and AST levels. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| 学科主题 | Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics |
| 类目[WOS] | Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics |
| 研究领域[WOS] | Chemistry ; Food Science & Technology ; Nutrition & Dietetics |
| 关键词[WOS] | LUCIDUM ; LANOSTANOIDS ; TSUGAE ; CYCLE |
| 收录类别 | SCI |
| 资助信息 | NSFC [81172940]; CAS [KSCX2-YW-G-038, KSCX2-YW-R-194]; Department of Science and Technology in Yunnan Province [20080A007]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ14] |
| 语种 | 英语 |
| WOS记录号 | WOS:000321803500038 |
| 公开日期 | 2013-10-16 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/16651]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,et al. Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells[J]. FOOD CHEMISTRY,2013,141(2):920-926. |
| APA | Peng, Xing-Rong,Liu, Jie-Qing,Han, Zhong-Hui,Yuan, Xiao-Xi,Luo, Huai-Rong,&Qiu, Ming-Hua.(2013).Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells.FOOD CHEMISTRY,141(2),920-926. |
| MLA | Peng, Xing-Rong,et al."Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells".FOOD CHEMISTRY 141.2(2013):920-926. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。