中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer (RATICAL): a nationwide multicenter retrospective study

文献类型：期刊论文

作者Li, Lin23; Li, Wencai5; Wu, Chunyan30; Xi, Yanfeng31; Guo, Lei23; Ji, Yuan32; Jiang, Lili22; Li, Ji6; Yun, Jingping7,8,9; Chen, Gang10
刊名CANCER COMMUNICATIONS
出版日期2024-07-17
关键词anaplastic lymphoma kinase diagnosis gene fusion non-small cell lung cancer
DOI10.1002/cac2.12593
通讯作者Ying, Jianming(jmying@cicams.ac.cn)
英文摘要Background: Anaplastic lymphoma kinase (ALK) test in advanced non-small cell lung cancer (NSCLC) can help physicians provide target therapies for patients harboring ALK gene rearrangement. This study aimed to investigate the real-world test patterns and positive rates of ALK gene rearrangements in advanced NSCLC. Methods: In this real-world study (ChiCTR2000030266), patients with advanced NSCLC who underwent an ALK rearrangement test in 30 medical centers in China between October 1, 2018 and December 31, 2019 were retrospectively analyzed. Interpretation training was conducted before the study was initiated. Quality controls were performed at participating centers using immunohistochemistry (IHC)-VENTANA-D5F3. The positive ALK gene rearrangement rate and consistency rate were calculated. The associated clinicopathological characteristics of ALK gene rearrangement were investigated as well. Results: The overall ALK gene rearrangement rate was 6.7% in 23,689 patients with advanced NSCLC and 8.2% in 17,436 patients with advanced lung adenocarcinoma. The quality control analysis of IHC-VENTANA-D5F3 revealed an intra-hospital consistency rate of 98.2% (879/895) and an inter-hospital consistency rate of 99.2% (646/651). IHC-VENTANA-D5F3 was used in 53.6%, real-time polymerase chain reaction (RT-PCR) in 25.4%, next-generation sequencing (NGS) in 18.3%, and fluorescence in-situ hybridization (FISH) in 15.9% in the adenocarcinoma subgroup. For specimens tested with multiple methods, the consistency rates confirmed by IHC-VENTANA-D5F3 were 98.0% (822/839) for FISH, 98.7% (1,222/1,238) for NGS, and 91.3% (146/160) for RT-PCR. The overall ALK gene rearrangement rates were higher in females, patients of <= 35 years old, never smokers, tumor cellularity of > 50, and metastatic specimens used for testing in the total NSCLC population and adenocarcinoma subgroup (all P < 0.05). Conclusions: This study highlights the real-world variability and challenges of ALK test in advanced NSCLC, demonstrating a predominant use of IHC-VENTANA-D5F3 with high consistency and distinct clinicopathological features in ALK-positive patients. These findings underscore the need for a consensus on optimal test practices and support the development of refined ALK test strategies to enhance diagnostic accuracy and therapeutic decision-making in NSCLC.
WOS关键词GUIDE TARGETED THERAPY ; DRIVER MUTATIONS ; CRIZOTINIB ; NSCLC ; PREVALENCE ; FEATURES ; ASSAY ; FISH
资助项目CAMS Innovation Fund for Medical Sciences (CIFMS)[2021-1-I2M-012] ; CAMS Innovation Fund for Medical Sciences (CIFMS)[2022-I2M-CT-B-078] ; Beijing Hope Run Special Fund of Cancer Foundation of the People's Republic of China[LC2019L04] ; National Key Research and Development Program[2022YFC2409902] ; Capital's Funds for Health Improvement and Research[2020-2Z-4028]
WOS研究方向Oncology
语种英语
WOS记录号WOS:001269787500001
出版者WILEY
资助机构CAMS Innovation Fund for Medical Sciences (CIFMS) ; Beijing Hope Run Special Fund of Cancer Foundation of the People's Republic of China ; National Key Research and Development Program ; Capital's Funds for Health Improvement and Research
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/137155]  
专题中国科学院合肥物质科学研究院
通讯作者Ying, Jianming
作者单位1.Soochow Univ, Affiliated Hosp 1, Dept Pathol, Suzhou, Jiangsu, Peoples R China
2.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pathol, Wuhan, Hubei, Peoples R China
3.Harbin Med Univ, Canc Hosp, Dept Pathol, Harbin, Heilongjiang, Peoples R China
4.Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha, Hunan, Peoples R China
5.Zhengzhou Univ, Dept Pathol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China
6.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Pathol, Beijing, Peoples R China
7.Sun Yat Sen Univ, Canc Ctr, Dept Pathol, Guangzhou, Guangdong, Peoples R China
8.State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China
9.Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China
10.Fujian Med Univ, Fujian Canc Hosp, Dept Pathol, Canc Hosp, Fuzhou, Fujian, Peoples R China
推荐引用方式
GB/T 7714		 Li, Lin,Li, Wencai,Wu, Chunyan,et al. Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer (RATICAL): a nationwide multicenter retrospective study[J]. CANCER COMMUNICATIONS,2024.
APA Li, Lin.,Li, Wencai.,Wu, Chunyan.,Xi, Yanfeng.,Guo, Lei.,...&Ying, Jianming.(2024).Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer (RATICAL): a nationwide multicenter retrospective study.CANCER COMMUNICATIONS.
MLA Li, Lin,et al."Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer (RATICAL): a nationwide multicenter retrospective study".CANCER COMMUNICATIONS (2024).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。