A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis
文献类型：期刊论文
| 作者 | Liu, Jinhua1; Mu, Chenglong1; Yue, Wen2; Li, Jie1; Ma, Biao1; Zhao, Lixia2; Liu, Lei2; Chen, Quan1,2; Yan, Chen3; Liu, Haiyang3
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| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
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| 出版日期 | 2013-10-01 |
| 卷号 | 63期号:SI页码:485-494 |
| 关键词 | Thioredoxin reductase Bim ROS Apoptosis Cancer |
| ISSN号 | 0891-5849 |
| 通讯作者 | Zhu, YS (reprint author), Nankai Univ, Coll Life Sci, Tianjin Key Lab Prot Sci, Tianjin 300071, Peoples R China. ; zhuys@nankai.edu.cn |
| 英文摘要 | We have previously shown that the natural diterpenoid derivative S3 induced Bim upregulation and apoptosis in a Bax/Bak-independent manner. However, the exact molecular target(s) of S3 and the mechanism controlling Bim upregulation are still not clear. Here, we identify that S3 targets the selenoproteins TrxR1 and TrxR2 at the selenocysteine residue of the reactive center of the enzymes and inhibits their antioxidant activities. Consequently, cellular ROS is elevated, leading to the activation of FOXO3a, which contributes to Bim upregulation in Bax/Bak-deficient cells. Moreover, S3 retards tumor growth in subcutaneous xenograft tumors by inhibiting TrxR activity in vivo. Our studies delineate the signaling pathway controlling Bim upregulation, which results in Bax/Bak-independent apoptosis and provide evidence that the compounds can act as anticancer agents based on mammalian TrxRs inhibition. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Biochemistry & Molecular Biology; Endocrinology & Metabolism |
| 类目[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | FORKHEAD TRANSCRIPTION FACTOR ; MAMMALIAN THIOREDOXIN ; CELL-DEATH ; GROWTH-INHIBITION ; GENE-EXPRESSION ; CANCER-THERAPY ; BREAST-CANCER ; RAT-LIVER ; SYSTEM ; BAX |
| 收录类别 | SCI |
| 资助信息 | Ministry of Science and Technology of China [2010CB912204, 2011CB910903, 2013CB531200]; National Natural Science Foundation of China [31271529, 91213304, U1032603] |
| 语种 | 英语 |
| WOS记录号 | WOS:000323094700050 |
| 公开日期 | 2013-10-16 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/16657]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Nankai Univ, Coll Life Sci, Tianjin Key Lab Prot Sci, Tianjin 300071, Peoples R China 2.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jinhua,Mu, Chenglong,Yue, Wen,et al. A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis[J]. FREE RADICAL BIOLOGY AND MEDICINE,2013,63(SI):485-494. |
| APA | Liu, Jinhua.,Mu, Chenglong.,Yue, Wen.,Li, Jie.,Ma, Biao.,...&Zhu, Yushan.(2013).A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.FREE RADICAL BIOLOGY AND MEDICINE,63(SI),485-494. |
| MLA | Liu, Jinhua,et al."A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis".FREE RADICAL BIOLOGY AND MEDICINE 63.SI(2013):485-494. |
入库方式： OAI收割
来源：昆明植物研究所
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