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Prognostic value of lymphocytes in patients with breast cancer receiving radiotherapy after breast-conserving surgery: A post hoc analysis of a phase III randomized trial

文献类型：期刊论文

作者Song, Yu-Chun1; Chen, Si-Ye1; Zhao, Xu-Ran1; Jing, Hao1; Fang, Hui1; Tang, Yu1; Hu, Shang-Ying3; Song, Yong-Wen1; Jin, Jing1; Liu, Yue-Ping1
刊名RADIOTHERAPY AND ONCOLOGY
出版日期2024-10-01
卷号199
关键词Breast cancer Lymphocyte Radiotherapy Breast-conserving surgery Prognosis
ISSN号0167-8140
DOI10.1016/j.radonc.2024.110390
通讯作者Liu, Juan(liu.juan@zs-hospital.sh.cn) ; Li, Ye-Xiong(yexiong12@163.com) ; Wang, Shu-Lian(wangsl@cicams.ac.cn)
英文摘要Purpose: To evaluate the prognostic value of peripheral lymphocyte count (PLC) in the breast cancer patients after breast-conserving surgery (BCS) with radiotherapy (RT). Methods and Materials: This post hoc analysis was performed using data of 628 patients from a phase III, randomized controlled trial comparing hypofractionated RT (HFRT) with conventional fractionated RT (CFRT) after BCS. PLCs were obtained before, during, and after RT until the 1-year follow-up. The optimal cut-off PLCs were determined using the maxstat package in R. Survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test. Results: A total of 275 (46.1 %) patients developed lymphopenia during RT, among them, 17 (2.8 %) had grade 3 lymphopenia and no one developed grade 4 lymphopenia. With a median follow-up of 110.8 months, patients with pre-RT PLCs of < 1.77 x 10(9)/L had a significantly lower 10-year breast cancer-specific survival (BCSS) rate (P = 0.013) and overall survival (OS) rate (P = 0.026). Patients with a nadir PLC of < 1.35 x 10(9)/L had a significantly poorer 10-year OS rate (P = 0.048). Multivariate analysis showed that a pre-RT PLC of < 1.77 x 10(9)/L was an independent factor influencing BCSS and OS, while the effect of the nadir PLC did not remain significant. Neither PLC nor lymphopenia recovery at post-RT 1, 3, and 6 months and 1 year was associated with survival. Conclusions: Radiation-induced lymphopenia in patients with breast cancer after BCS tends to be mild. The lower pre-RT PLC predicted poorer survival.
WOS关键词RADIATION-INDUCED LYMPHOPENIA ; RECOVERY ; INTERLEUKIN-7 ; MASTECTOMY ; SURVIVAL ; COUNTS
资助项目National Natural Science Foundation of China[81972860] ; Beijing Marathon of Hope, Cancer Foundation of China[LC2012A11]
WOS研究方向Oncology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:001273759200001
出版者ELSEVIER IRELAND LTD
资助机构National Natural Science Foundation of China ; Beijing Marathon of Hope, Cancer Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/137253]  
专题中国科学院合肥物质科学研究院
通讯作者Liu, Juan; Li, Ye-Xiong; Wang, Shu-Lian
作者单位1.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Dept Radiat Oncol,Canc Hosp, Beijing 100021, Peoples R China
2.Fudan Univ, Zhongshan Hosp, Dept Radiat Oncol, Shanghai, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Dept Canc Epidemiol,Canc Hosp, Beijing 100021, Peoples R China
4.Minist Hlth, Beijing Hosp, Dept Radiat Oncol, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Radiat Therapy, Hangzhou, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Song, Yu-Chun,Chen, Si-Ye,Zhao, Xu-Ran,et al. Prognostic value of lymphocytes in patients with breast cancer receiving radiotherapy after breast-conserving surgery: A post hoc analysis of a phase III randomized trial[J]. RADIOTHERAPY AND ONCOLOGY,2024,199.
APA Song, Yu-Chun.,Chen, Si-Ye.,Zhao, Xu-Ran.,Jing, Hao.,Fang, Hui.,...&Wang, Shu-Lian.(2024).Prognostic value of lymphocytes in patients with breast cancer receiving radiotherapy after breast-conserving surgery: A post hoc analysis of a phase III randomized trial.RADIOTHERAPY AND ONCOLOGY,199.
MLA Song, Yu-Chun,et al."Prognostic value of lymphocytes in patients with breast cancer receiving radiotherapy after breast-conserving surgery: A post hoc analysis of a phase III randomized trial".RADIOTHERAPY AND ONCOLOGY 199(2024).

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来源：合肥物质科学研究院

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