Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice
文献类型：期刊论文
| 作者 | Guo, Ruo-Wen3,4; Xie, Wen-Jing2,4; Yu, Biao4 ; Song, Chao4; Ji, Xin-Miao4; Wang, Xin-Yu2,4; Zhang, Mei1; Zhang, Xin2,3,4
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| 刊名 | ZOOLOGICAL RESEARCH
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| 出版日期 | 2024-07-18 |
| 卷号 | 45 |
| 关键词 | Alzheimer's disease Rotating magnetic field Amyloid-beta Cognitive function Alzheimer's disease animal models |
| ISSN号 | 2095-8137 |
| DOI | 10.24272/j.issn.2095-8137.2024.034 |
| 通讯作者 | Zhang, Xin(xinzhang@hmfl.ac.cn) |
| 英文摘要 | Amyloid beta (A beta) monomers aggregate to form fibrils and amyloid plaques, which are critical mechanisms in the pathogenesis of Alzheimer's disease (AD). Given the important role of A beta 1-42 aggregation in plaque formation, leading to brain lesions and cognitive impairment, numerous studies have aimed to reduce A beta aggregation and slow AD progression. The diphenylalanine (FF) sequence is critical for amyloid aggregation, and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic rings. In this study, we examined the effects of a moderate-intensity rotating magnetic field (RMF) on A beta aggregation and AD pathogenesis. Results indicated that the RMF directly inhibited A beta amyloid fibril formation and reduced A beta-induced cytotoxicity in neural cells in vitro . Using the AD mouse model APP/PS1, RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments, including exploration and spatial and non-spatial memory abilities. Tissue examinations demonstrated that RMF reduced amyloid plaque accumulation, attenuated microglial activation, and reduced oxidative stress in the APP/PS1 mouse brain. These findings suggest that RMF holds considerable potential as a non-invasive, high-penetration physical approach for AD treatment. |
| WOS关键词 | MANAGEMENT |
| 资助项目 | National Key R&D Program of China[2023YFB3507004] ; National Natural Science Foundation of China[U21A20148] ; International Partnership Program of Chinese Academy of Sciences[116134KYSB20210052] ; Heye Health Technology Chong Ming Project[HYCMP2021010] ; CASHIPS Director's Fund[BJPY2021A06] |
| WOS研究方向 | Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:001272410200016 |
| 出版者 | SCIENCE PRESS |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; International Partnership Program of Chinese Academy of Sciences ; Heye Health Technology Chong Ming Project ; CASHIPS Director's Fund |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/137259]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Div Life Sci & Med, Hefei 230026, Anhui, Peoples R China 2.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China 3.Univ Sci & Technol China, Sci Isl Branch, Grad Sch, Hefei 230036, Anhui, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Ruo-Wen,Xie, Wen-Jing,Yu, Biao,et al. Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice[J]. ZOOLOGICAL RESEARCH,2024,45. |
| APA | Guo, Ruo-Wen.,Xie, Wen-Jing.,Yu, Biao.,Song, Chao.,Ji, Xin-Miao.,...&Zhang, Xin.(2024).Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice.ZOOLOGICAL RESEARCH,45. |
| MLA | Guo, Ruo-Wen,et al."Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice".ZOOLOGICAL RESEARCH 45(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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