Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway
文献类型：期刊论文
| 作者 | Wei, Xin1,2; Liu, Qunshan2; Liu, Liu2; Wang, Dan2; Liu, Jiajia2; Zhu, Qizhi1,2; Xu, Ziming2; Chen, Qi1,2; Xu, Weiping1,2,3 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2024-07-01 |
| 卷号 | 25 |
| 关键词 | Erianin gastric cancer LKB1 PARD3 epithelial to mesenchymal transition 5-FU |
| ISSN号 | 1661-6596 |
| DOI | 10.3390/ijms25147973 |
| 通讯作者 | Xu, Weiping(weipingx@ustc.edu.cn) |
| 英文摘要 | Erianin, a bibenzyl compound found in dendrobium extract, has demonstrated broad anticancer activity. However, its mechanism of action in gastric cancer (GC) remains poorly understood. LKB1 is a tumor-suppressor gene, and its mutation is an important driver of various cancers. Yet some studies have reported contradictory findings. In this study, we combined bioinformatics and in vitro and in vivo experiments to investigate the effect and potential mechanism of Erianin in the treatment of GC. The results show that LKB1 was highly expressed in patients' tumor tissues and GC cells, and it was associated with poor patient prognosis. Erianin could promote GC cell apoptosis and inhibit the scratch repair, migration, invasion, and epithelial-mesenchymal transition (EMT) characteristics. Erianin dose-dependently inhibited the expression of LKB1, SIK2, SIK3, and PARD3 but had no significant effect on SIK1. Erianin also inhibited tumor growth in CDX mice model. Unexpectedly, 5-FU also exhibited a certain inhibitory effect on LKB1. The combination of Erianin and 5-FU significantly improved the anti-tumor efficacy of 5-FU in the growth of GC cells and xenograft mouse models. In summary, Erianin is a potential anti-GC compound that can inhibit GC growth and EMT properties by targeting the LKB1-SIK2/3-PARD3-signaling axis. The synergistic effect of Erianin and 5-FU suggests a promising therapeutic strategy for GC treatment. |
| WOS关键词 | SALT-INDUCIBLE KINASE ; TUMOR-SUPPRESSOR ; LKB1 ; EXPRESSION ; EPIDEMIOLOGY ; CHEMOTHERAPY ; METAANALYSIS ; METASTASIS ; PACLITAXEL ; RESISTANCE |
| 资助项目 | National Natural Science Foundation of China[52072360] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001277703100001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/137350]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, Weiping |
| 作者单位 | 1.Chinese Acad Sci, Inst Intelligent Machines, Hefei Inst Phys Sci, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Div Life Sci & Med, Hefei 230026, Peoples R China 3.Anhui Prov Key Lab Tumor Immunotherapy & Nutr Ther, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Xin,Liu, Qunshan,Liu, Liu,et al. Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25. |
| APA | Wei, Xin.,Liu, Qunshan.,Liu, Liu.,Wang, Dan.,Liu, Jiajia.,...&Xu, Weiping.(2024).Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25. |
| MLA | Wei, Xin,et al."Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25(2024). |
入库方式： OAI收割
来源：合肥物质科学研究院
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