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Nonfluorescent Near-Infrared Surface-Enhanced Resonance Raman Nanoprobes with Ultrahigh Brightness and Synergistic Photothermal Effect

文献类型：期刊论文

作者Qi, Caixia1; Shen, Lin1,4; Li, Jin4; Sun, Xun1; Song, Lehui4; Chen, Jiadong2; Wu, Yixuan2,4; Choo, Jaebum2; Chen, Lingxin3,4
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2024-11-27
卷号16期号:49页码:67333-67343
关键词black hole quencher SERRS synergisticphotothermaleffect cellular imaging photothermal therapy
ISSN号1944-8244
DOI10.1021/acsami.4c15017
通讯作者Li, Jin(jinli@yic.ac.cn) ; Sun, Xun(sunxun@ytu.edu.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Near-infrared (NIR) surface-enhanced resonance Raman (SERRS) nanoprobes have found wide applications in biomedicine; however, almost all of these nanoprobes are fluorescent because the resonant Raman dyes used cannot be fully quenched onto the underlying plasmonic nanoparticles. Therefore, suppressing the fluorescence backgrounds in resonant Raman spectroscopy imaging is extremely important. In this work, we use a black hole quencher, IQ1, as a Raman dye to develop absolutely nonfluorescent NIR resonant SERRS NPs. Ultrafast spectroscopy clarifies that the nonfluorescent mechanism of the dyes is attributed to the ultrafast internal conversion at the subpicosecond scale, which quenches the fluorescence of excited states. The resultant nanoprobes exhibit zero fluorescent background, femtomolar-level sensitivity (100 fM) as well as superb photostability (tau = 10006 s) without fluorescence photobleaching, outperforming that of fluorescent counterparts. More importantly, the SERRS NPs show a synergistic photothermal effect originating from the dye molecule-plasmon interactions, achieving a high photothermal conversion efficiency of 64.94%. Featuring these excellent properties, these SERRS NPs allow for longitudinally photostable cellular imaging and enhanced photothermal elimination of cancer cells. To the best of our knowledge, this is the first example of absolutely nonfluorescent NIR SERRS NPs, opening up promising applications for improved phototheranostics.
WOS关键词SINGLE-MOLECULE ; DARK QUENCHER ; SCATTERING ; NANOPARTICLES ; DYES
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001364991700001
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Shandong Natural Science Foundation ; National Research Foundation of Korea
源URL[http://ir.yic.ac.cn/handle/133337/38112]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Li, Jin; Sun, Xun; Chen, Lingxin
作者单位1.Yantai Univ, Shandong Appl Res Ctr Gold Nanotechnol Au SDARC, Sch Chem & Chem Engn, Yantai 264005, Peoples R China
2.Chung Ang Univ, Dept Chem, Seoul 06974, South Korea
3.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Qi, Caixia,Shen, Lin,Li, Jin,et al. Nonfluorescent Near-Infrared Surface-Enhanced Resonance Raman Nanoprobes with Ultrahigh Brightness and Synergistic Photothermal Effect[J]. ACS APPLIED MATERIALS & INTERFACES,2024,16(49):67333-67343.
APA Qi, Caixia.,Shen, Lin.,Li, Jin.,Sun, Xun.,Song, Lehui.,...&Chen, Lingxin.(2024).Nonfluorescent Near-Infrared Surface-Enhanced Resonance Raman Nanoprobes with Ultrahigh Brightness and Synergistic Photothermal Effect.ACS APPLIED MATERIALS & INTERFACES,16(49),67333-67343.
MLA Qi, Caixia,et al."Nonfluorescent Near-Infrared Surface-Enhanced Resonance Raman Nanoprobes with Ultrahigh Brightness and Synergistic Photothermal Effect".ACS APPLIED MATERIALS & INTERFACES 16.49(2024):67333-67343.

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来源：烟台海岸带研究所

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