Chemical Warfare in the Environment-Secondary Metabolites From Starfish (Asterias amurensis) Induce Teratogenicity in Medaka Embryos (Oryzias melastigma)
文献类型：期刊论文
| 作者 | Lu, Zhen2; Wang, Derui2,3; Li, Xiaodong2; Yan, Zhi2; Yin, Xiuli2 ; Xu, Youhou3; Wang, Song1; Li, Ke2,4
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2024-12-07 |
| 页码 | 8 |
| 关键词 | chemical defense embryotoxicity malformation oligoglycoside |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202402115 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | Starfish saponins, known for their role as feeding deterrents against predators like crabs and fish, have been extensively studied for their antifeedant and cytolytic effects. Recent research suggests that starfish secondary metabolites possess antifouling and antifeedant properties and play a role in biological interactions and various ecological functions. Previous research demonstrated that saponins from starfish exert their toxic effects on fish by interacting with cholesterol in the blood cell membrane. This study investigated the hypothesis that secondary metabolites, other than saponins, from the starfish Asterias amurensis may be harmful to fish eggs, particularly marine medaka (Oryzias melastigma) eggs, which share starfish habitat. We systematically separated the secondary metabolites of A. amurensis by a variety of chromatographic methods. Two oligoglycosides related to embryonic teratogenicity were identified, including one previously undescribed tetrasaccharide (1) and one known pyrrole oligoglycoside (2). Their structures were established mainly on the basis of detailed analysis of the nuclear magnetic resonance spectroscopy (NMR) and mass spectroscopic data. Compounds 1 and 2 exhibited strong lethality and significantly reduced voluntary movements in medaka embryos, with compound 2 showing more pronounced effects on teratogenicity and heart rates. The main morphological abnormalities observed included delayed head development (DHD), tiny spines (TS), incomplete absorption of oil balls (OB), cardiac abnormalities (CA), and shrunken yolk sacs (SYS). Our findings imply that starfish secondary metabolites may have broader ecological effects, influencing habitat-sharing species in subtle but crucial ways. |
| WOS关键词 | SEA STARS ; DEFENSES ; ECOLOGY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001374072200001 |
| 资助机构 | National Natural Science Foundation of China ; STS Program of Chinese Academy of Sciences ; Fundamental Research Projects of Science & Technology Innovation and Development Plan in Yantai City ; Center for ocean megascience, Chinese academy of sciences ; Yantai Institute of Coastal Zone Research's seed project ; Yantai Municipal City's Shuangbai Plan |
| 源URL | [http://ir.yic.ac.cn/handle/133337/38166]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Lianyungang, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 3.Beibu Gulf Univ, Coll Marine Sci, Qinzhou, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Zhen,Wang, Derui,Li, Xiaodong,et al. Chemical Warfare in the Environment-Secondary Metabolites From Starfish (Asterias amurensis) Induce Teratogenicity in Medaka Embryos (Oryzias melastigma)[J]. CHEMISTRY & BIODIVERSITY,2024:8. |
| APA | Lu, Zhen.,Wang, Derui.,Li, Xiaodong.,Yan, Zhi.,Yin, Xiuli.,...&Li, Ke.(2024).Chemical Warfare in the Environment-Secondary Metabolites From Starfish (Asterias amurensis) Induce Teratogenicity in Medaka Embryos (Oryzias melastigma).CHEMISTRY & BIODIVERSITY,8. |
| MLA | Lu, Zhen,et al."Chemical Warfare in the Environment-Secondary Metabolites From Starfish (Asterias amurensis) Induce Teratogenicity in Medaka Embryos (Oryzias melastigma)".CHEMISTRY & BIODIVERSITY (2024):8. |
入库方式： OAI收割
来源：烟台海岸带研究所
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