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Synthesis and antioxidant evaluation of coumarin-functionalised chitosan: A potent, non-toxic free radical scavenging compound

文献类型：期刊论文

作者Zhu, Siyu1,5; Miao, Qin5; Chen, Qiuhong3,4; Tian, Liguang2; Dong, Fang5; Guo, Zhanyong5; Li, Qing5
刊名CARBOHYDRATE RESEARCH
出版日期2025-02-01
卷号548页码:11
关键词Chitosan Coumarins Antioxidant activity
ISSN号0008-6215
DOI10.1016/j.carres.2024.109311
通讯作者Guo, Zhanyong(zhanyongguo@hotmail.com) ; Li, Qing(qli@yic.ac.cn)
英文摘要In the present study, we designed to link the coumarin molecule to chitosan via a triazole group and synthesized chitosan-coumarin derivatives, which were further quaternized in one step in order to further improve their solubility to obtain a second series of chitosan-coumarin ammonium salt derivatives. The structures of these chitosan derivatives were verified by FT-IR and 1 H NMR. They were tested for their antioxidant activities. The experimental results showed that the derivatives had excellent free radical scavenging ability. The introduction of the coumarin moiety significantly improved the antioxidant activity, and the scavenging capacity was much higher than that of the chitosan feedstock in all three antioxidant tests. Overall, the scavenging capacity of chitosan-coumarin ammonium salt derivatives was slightly higher than that of chitosan-coumarin derivatives, with the highest scavenging rates in all three tests. Compound 8B scavenged 98.74 % (0.01 mg/mL) of superoxide anion radicals, compound 8D scavenged 95.5 % (0.3 mg/mL) of DPPH radicals and compound 8A scavenged 92.97 % (0.2 mg/mL) of hydroxyl radicals. Toxicity assays used L929 cells demonstrated that there was no significant toxicity of the derivatives. The results indicated that the chitosan derivatives described herein were safe and non-toxic and have good antioxidant activity.
WOS关键词DERIVATIVES
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001375630800001
资助机构Natural Science Foundation of Shandong Province ; Shandong Key R D Plan ; Major Scientific and Technological Innovation Project ; The 2022 Central Guiding Local Science and Technology Development Fund Project in Shandong Province
源URL[http://ir.yic.ac.cn/handle/133337/38182]  
专题海岸带生物学与生物资源利用重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Guo, Zhanyong; Li, Qing
作者单位1.Harbin Inst Technol Weihai, Sch Marine Sci & Technol, Weihai 264209, Peoples R China
2.Yantai Agr Technol Extens Ctr, Yantai 264001, Peoples R China
3.Shandong Yinuokang Pharmaceut Co Ltd, Dongying 257091, Peoples R China
4.Jiangsu Ocean Univ, Lianyungang 222000, Peoples R China
5.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Siyu,Miao, Qin,Chen, Qiuhong,et al. Synthesis and antioxidant evaluation of coumarin-functionalised chitosan: A potent, non-toxic free radical scavenging compound[J]. CARBOHYDRATE RESEARCH,2025,548:11.
APA Zhu, Siyu.,Miao, Qin.,Chen, Qiuhong.,Tian, Liguang.,Dong, Fang.,...&Li, Qing.(2025).Synthesis and antioxidant evaluation of coumarin-functionalised chitosan: A potent, non-toxic free radical scavenging compound.CARBOHYDRATE RESEARCH,548,11.
MLA Zhu, Siyu,et al."Synthesis and antioxidant evaluation of coumarin-functionalised chitosan: A potent, non-toxic free radical scavenging compound".CARBOHYDRATE RESEARCH 548(2025):11.

入库方式： OAI收割

来源：烟台海岸带研究所

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