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Advance on the effects of algal carotenoids on inflammatory signaling pathways

文献类型：期刊论文

作者Wang, Yudi1,3; Geng, Xinrong1,3; Qin, Song1,3; Che, Tuanjie2; Yan, Libo2; Yuan, Biao4; Li, Wenjun1,3
刊名EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
出版日期2025-01-05
卷号281页码:13
关键词Algal carotenoids Inflammatory signaling pathways Targeting effect
ISSN号0223-5234
DOI10.1016/j.ejmech.2024.117020
通讯作者Yuan, Biao(yuanbiao@cpu.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn)
英文摘要The development of inflammation has an indispensable importance in the self-protection of the human body. However, over-inflammation may damage human health, and inflammatory pathways and inflammasomes have a significant impact on the onset of inflammation. Therefore, how to constrain the development of inflammation through inflammatory pathways or inflammasomes becomes a hot research issue. Carotenoids are a natural pigment and an active substance in algae, with anti-inflammatory and antioxidant effects. Many studies have shown that carotenoids have inhibitory effects on the inflammatory pathways and inflammasomes. In this review, we discussed the mechanism of carotenoids targeting those important inflammatory pathways and their effects on common inflammasome NLRP3 and inflammation-related diseases from the perspective of several inflammatory pathways, including p38 MAPK, IL-6/JAK/STAT3, and PI3K, with a focus on the targets and targeting effects of carotenoids on different inflammatory signaling pathways, and at last proposed possible antiinflammatory targets.
WOS关键词TRANS-RETINOIC ACID ; NF-KAPPA-B ; BETA-CAROTENE ; MOLECULAR-MECHANISMS ; SAFETY EVALUATION ; FUCOXANTHIN ; ACTIVATION ; APOPTOSIS ; LUTEIN ; CELLS
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001356491900001
资助机构National Key Research and Devel-opment Program of China ; Funda-mental Research Funds for the Central Universities
源URL[http://ir.yic.ac.cn/handle/133337/38220]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Yuan, Biao; Li, Wenjun
作者单位1.Shandong Univ Tradit Chinese Med, Inst Marine Tradit Chinese Med, Qingdao 266112, Shandong, Peoples R China
2.Zhigong Biomed Co Ltd, Yantai 2640035, Shandong, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
4.China Pharmaceut Univ, Coll Engn, Natl R&D Ctr Chinese Herbal Med Proc, Dept Food Qual & Safety, Nanjing 211198, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yudi,Geng, Xinrong,Qin, Song,et al. Advance on the effects of algal carotenoids on inflammatory signaling pathways[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2025,281:13.
APA Wang, Yudi.,Geng, Xinrong.,Qin, Song.,Che, Tuanjie.,Yan, Libo.,...&Li, Wenjun.(2025).Advance on the effects of algal carotenoids on inflammatory signaling pathways.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,281,13.
MLA Wang, Yudi,et al."Advance on the effects of algal carotenoids on inflammatory signaling pathways".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 281(2025):13.

入库方式： OAI收割

来源：烟台海岸带研究所

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